NOAEL Data REACH Registered Cosmetic Ingredient

N-Dodecanoyl-N-methylglycine

Also known as: Glycine, N-methyl-N-(1-oxododecyl)-, N-Lauroylsarcosine, Sarcosine, N-lauroyl-, N-Methyl-N-(1-oxododecyl)glycine, EINECS 202-608-3 (+2 more)

CAS 97-78-9

N-Dodecanoyl-N-methylglycine (CAS 97-78-9) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Lauroyl Sarcosine →

Cross-Vertical Regulatory Divergence

N-Dodecanoyl-N-methylglycine is classified GHS Danger (H315, H318, H319, H330, H335) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields

Name

N-Dodecanoyl-N-methylglycine

CAS Number

97-78-9

DTXSID

DTXSID7042011

Molecular Formula

C15H29NO3

InChI Key

BACYUWVYYTXETD-UHFFFAOYSA-N

Monoisotopic Mass

271.214744

Synonyms

Glycine, N-methyl-N-(1-oxododecyl)-N-LauroylsarcosineSarcosine, N-lauroyl-N-Methyl-N-(1-oxododecyl)glycineEINECS 202-608-3N-Lauroyl sarcosinateUNII-LIJ19P3L6F

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 12 records

Surfactant (surface active agent)Anti-static agentCleaning agentSoftener and conditionerWetting agent (non-aqueous)

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
inert_ingredient; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 29 of 29 studies

Value	Unit	Endpoint	Route	Species	Source
42.07	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=141.053	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
LIJ19P3L6F	UNII	FDA UNII substance identifier	-	-	openFDA substances
LIJ19P3L6F	UNII	FDA UNII substance identifier	-	-	openFDA substances
LIJ19P3L6F	UNII	FDA UNII substance identifier	-	-	openFDA substances
LIJ19P3L6F	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.003219	fraction	Fu	-	Human	NTP_ICE_adme_parameters
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=30	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
=30	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
=30	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
=30	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
=96.2	%	NOAEL	oral	rat	CIR_vision_codex
=96.2	%	NOAEL	oral	rat	CIR_vision_codex
=96.2	%	NOAEL	oral	rat	CIR_vision_codex
=96.2	%	NOAEL	oral	rat	CIR_vision_codex
=250	mg/kg/day	NOAEL	-	-	CIR_vision_codex
=250	mg/kg/day	NOAEL	-	-	CIR_vision_codex
=250	mg/kg/day	NOAEL	-	-	CIR_vision_codex
=250	mg/kg/day	NOAEL	-	-	CIR_vision_codex
=1000	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
=1000	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
=1000	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
=1000	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
30	mg/kg/day	developmental toxicity	oral	rat	UnifiedCodex:CIR:beta.noael_studies
96.2	%	developmental toxicity	oral	rat	UnifiedCodex:CIR:beta.noael_studies
>=250	mg/kg/day	developmental toxicity	-	-	UnifiedCodex:CIR:beta.noael_studies
250	mg/kg/day	inhalation toxicity	oral	rat	UnifiedCodex:CIR:beta.noael_studies
1000	mg/kg/day	oral toxicity	oral	rat	UnifiedCodex:CIR:beta.noael_studies

Showing 29 of 29 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	N-lauroylsarcosine	202-608-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1907464

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for N-Dodecanoyl-N-methylglycine?

N-Dodecanoyl-N-methylglycine has 29 NOAEL studies in the database. The lowest reported value is 42.07 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include N-Dodecanoyl-N-methylglycine?

N-Dodecanoyl-N-methylglycine appears on 3 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018). Source: EPA CPDat.

Is N-Dodecanoyl-N-methylglycine used in cosmetics?

Yes, N-Dodecanoyl-N-methylglycine is also indexed as a cosmetic ingredient under the name Lauroyl Sarcosine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for N-Dodecanoyl-N-methylglycine come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does N-Dodecanoyl-N-methylglycine have different safety status in cosmetics vs industrial chemicals?

N-Dodecanoyl-N-methylglycine is classified GHS Danger (H315, H318, H319, H330, H335) in the chemicals database but is allowed in EU cosmetics.

Is N-Dodecanoyl-N-methylglycine used outside industrial chemicals?

N-Dodecanoyl-N-methylglycine also appears in cosmetics, pharmaceutical databases.