What is the NOAEL for N-Dodecanoyl-N-methylglycine?
N-Dodecanoyl-N-methylglycine has 14 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N-Dodecanoyl-N-methylglycine
Also known as: Glycine, N-methyl-N-(1-oxododecyl)-, N-Lauroylsarcosine, Sarcosine, N-lauroyl-, N-Methyl-N-(1-oxododecyl)glycine, EINECS 202-608-3 (+2 more)
CAS 97-78-9
N-Dodecanoyl-N-methylglycine (CAS 97-78-9) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
N-Dodecanoyl-N-methylglycine is classified GHS Danger (H315, H318, H319, H330, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
14
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
N-Dodecanoyl-N-methylglycine
CAS Number
97-78-9
Molecular Formula
C15H29NO3
InChI Key
BACYUWVYYTXETD-UHFFFAOYSA-N
Monoisotopic Mass
271.214744
Synonyms
Glycine, N-methyl-N-(1-oxododecyl)-N-LauroylsarcosineSarcosine, N-lauroyl-N-Methyl-N-(1-oxododecyl)glycineEINECS 202-608-3N-Lauroyl sarcosinateUNII-LIJ19P3L6F
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
Surfactant (surface active agent)Anti-static agentCleaning agentSoftener and conditionerWetting agent (non-aqueous)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 42.07 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| =141.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| LIJ19P3L6F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.003219 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =30 | mg/kg/day | NOAEL | oral | rat | CIR Safety Assessment |
| =96.2 | % | NOAEL | oral | rat | CIR Safety Assessment |
| =250 | mg/kg/day | NOAEL | - | - | CIR Safety Assessment |
| =1000 | mg/kg/day | NOAEL | oral | rat | CIR Safety Assessment |
| 30 | mg/kg/day | developmental toxicity | oral | rat | Regulatory source |
| 96.2 | % | developmental toxicity | oral | rat | Regulatory source |
| >=250 | mg/kg/day | developmental toxicity | - | - | Regulatory source |
| 250 | mg/kg/day | inhalation toxicity | oral | rat | Regulatory source |
| 1000 | mg/kg/day | oral toxicity | oral | rat | Regulatory source |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | N-lauroylsarcosine | 202-608-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL1907464
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include N-Dodecanoyl-N-methylglycine?
N-Dodecanoyl-N-methylglycine appears on 3 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is N-Dodecanoyl-N-methylglycine used in cosmetics?
Yes, N-Dodecanoyl-N-methylglycine is also indexed as a cosmetic ingredient under the name Lauroyl Sarcosine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N-Dodecanoyl-N-methylglycine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does N-Dodecanoyl-N-methylglycine have different safety status in cosmetics vs industrial chemicals?
N-Dodecanoyl-N-methylglycine is classified GHS Danger (H315, H318, H319, H330, H335) in the chemicals database but is allowed in EU cosmetics.
Is N-Dodecanoyl-N-methylglycine used outside industrial chemicals?
N-Dodecanoyl-N-methylglycine also appears in cosmetics, pharmaceutical databases.