Also known as: Glycine, N-methyl-N-(1-oxododecyl)-, N-Lauroylsarcosine, Sarcosine, N-lauroyl-, N-Methyl-N-(1-oxododecyl)glycine, EINECS 202-608-3 (+2 more)
INCI: LAUROYL SARCOSINE
Lauroyl Sarcosine (CAS 97-78-9) is a cosmetic cosmetic ingredient functioning as Surfactant — cleansing agent, hair conditioning agent. Reported NOAEL =30 mg/kg/day in rat (CIR Safety Assessment); EU Regulation 1223/2009 status: permitted; 2 safety opinions reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Lauroyl Sarcosine is classified GHS Danger (H315, H318, H319, H330, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Lauroyl Sarcosine.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Lauroyl Sarcosine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =30 mg/kg/day | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =30 mg/kg/day | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =30 mg/kg/day | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =30 mg/kg/day | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =250 mg/kg/day | - | - | developmental toxicity | CIR Safety Assessment |
| NOAEL | =250 mg/kg/day | - | - | developmental toxicity | CIR Safety Assessment |
| NOAEL | =250 mg/kg/day | - | - | developmental toxicity | CIR Safety Assessment |
| NOAEL | =250 mg/kg/day | - | - | developmental toxicity | CIR Safety Assessment |
| NOAEL | =1000 mg/kg/day | oral | rat | oral toxicity | CIR Safety Assessment |
| NOAEL | =1000 mg/kg/day | oral | rat | oral toxicity | CIR Safety Assessment |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
the Panel published a safety assessment with the conclusion that 5 fatty acyl sarcosines and 5 sarcosinate salts are safe as used in rinse-off products, safe for use in leave-on products at concentrations of ≤5%, and the data are insufficient to determine the safety for use in products where the fatty acyl sarcosines and
the Panel published a safety assessment with the conclusion that 5 fatty acyl sarcosines and 5 sarcosinate salts are safe as used in rinse-off products, safe for use in leave-on products at concentrations of ≤5%, and the data are insufficient to determine the safety for use in products where the fatty acyl sarcosines and
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Preliminary editorial summary for Lauroyl Sarcosine — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Lauroyl Sarcosine by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Lauroyl Sarcosine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Lauroyl Sarcosine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Lauroyl Sarcosine functions as: Surfactant — cleansing agent, hair conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 97-78-9.
The NOAEL (No Observed Adverse Effect Level) for Lauroyl Sarcosine is =30 mg/kg/day based on a developmental toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR Safety Assessment.
Lauroyl Sarcosine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Lauroyl Sarcosine is classified GHS Danger (H315, H318, H319, H330, H335) in the chemicals database but is allowed in EU cosmetics.
Check Lauroyl Sarcosine compliance across multiple jurisdictions:
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