Warning GHS02GHS07 NOAEL Data IARC Group 2B REACH Registered Cosmetic Ingredient

Butyl methacrylate

Also known as: 2-Propenoic acid, 2-methyl-, butyl ester, BRN 0773960, Butylmethacrylate, EINECS 202-615-1, 2-Methylacrylic acid, butyl ester (+8 more)

CAS 97-88-1

Butyl methacrylate (CAS 97-88-1) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H335; H315; H319; H317. Key regulatory status: REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Butyl Methacrylate →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields

Name

Butyl methacrylate

CAS Number

97-88-1

Molecular Formula

C8H14O2

InChI Key

SOGAXMICEFXMKE-UHFFFAOYSA-N

Monoisotopic Mass

142.09938

Synonyms

2-Propenoic acid, 2-methyl-, butyl esterBRN 0773960ButylmethacrylateEINECS 202-615-12-Methylacrylic acid, butyl ester2-Methyl-butylacrylate2-Methyl-butylacrylaat2-Methyl-butylacrylatButil metacrilatoButylester kyseliny methakryloveButylmethacrylaatMethacrylsaeurebutylester

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 2B	Possibly carcinogenic	2023	133

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 3; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1	H226; H335; H315; H319; H317	GHS02; GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Flammable liquid and vapour Causes skin and eye irritation May cause an allergic skin reaction May cause respiratory irritation May be harmful if swallowed and enters airways Harmful to aquatic life
Short-term Effects	Lachrymation. The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. Medical observation is indicated.
Long-term Effects	Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure	The substance can be absorbed into the body by inhalation.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 11 records

Film formerDeodorizerViscosity modifierBinderFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 23 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
detected; Europe; Personal care - nails - nail polish	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - nails	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - nails - nail polish	Danish Environmental Protection Agency	Danish EPA
consumer_product; Europe	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
consumer_product	P&G	Proctor & Gamble
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Cons electronics mech appliances and machinery; detected; Europe	Danish EPA	Danish EPA
Cons electronics mech appliances and machinery; detected; Europe	Danish EPA	Danish EPA
Cons electronics mech appliances and machinery; detected; Europe	Danish EPA	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
detected; Europe; Personal care - nails - nail polish	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - nails	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - nails - nail polish	Danish Environmental Protection Agency	Danish EPA
consumer_product; Europe	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
consumer_product	P&G	Proctor & Gamble
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 36 of 36 studies

Value	Unit	Endpoint	Route	Species	Source
=409	mg/m3	DNEL local	inhalation	Human	ToxValDB GESTIS DNEL
=415.9	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
R5QX287XXU	UNII	FDA UNII substance identifier	-	-	openFDA substances
2B	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
28.54	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
>2000	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1.600e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=2.260e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
>=1163	mg/m3	LEL	inhalation	Rat	ECHA
=6000	mg/m3	LEL	inhalation	Rat	ECHA
=1.970e+4	mg/m3	LEL	inhalation	Rat	ECHA
=2.900e+4	mg/m3	LEL	inhalation	Rat	ECHA
=5537	mg/m3	LOAEC	inhalation	Rat	ECHA
=581.6	mg/m3	NOAEC	inhalation	Rat	ECHA
=1745	mg/m3	NOAEC	inhalation	Rat	ECHA
=1803	mg/m3	NOAEC	inhalation	Rat	ECHA
=1.100e+4	mg/m3	NOAEC	inhalation	Rat	ECHA
=30	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=100	mg/kg bw/day	NOAEL	oral	Rabbit	ECHA
=120	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=300	mg/kg bw/day	NOAEL	oral	Rabbit	ECHA
=360	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=1000	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=3501	mg/m3	NOAEL	inhalation	Rat	ECHA
0	%	Positive reaction	Dermal	Human	NTP ICE skin irritation
10.65	%	Viability	Dermal	-	NTP ICE skin irritation
11.25	%	Viability	Dermal	-	NTP ICE skin irritation
22.5	%	Viability	Dermal	-	NTP ICE skin irritation
25.6	%	Viability	Dermal	-	NTP ICE skin irritation
28.7	%	Viability	Dermal	-	NTP ICE skin irritation
39.2	%	Viability	Dermal	-	NTP ICE skin irritation
39.8	%	Viability	Dermal	-	NTP ICE skin irritation
59.5	%	Viability	Dermal	-	NTP ICE skin irritation
66.3	%	Viability	Dermal	-	NTP ICE skin irritation
92.64	%	Viability	Dermal	-	NTP ICE skin irritation
98.11	%	Viability	Dermal	-	NTP ICE skin irritation

Showing 36 of 36 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Butyl methacrylate	202-615-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL3183073

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Butyl methacrylate?

Butyl methacrylate (CAS 97-88-1) is classified under EU CLP Annex VI as Flam. Liq. 3; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 with signal word Warning. Hazard statements: H226; H335; H315; H319; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Butyl methacrylate?

Butyl methacrylate has 36 NOAEL studies in the database. The lowest reported value is 409 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.

What regulatory lists include Butyl methacrylate?

Butyl methacrylate appears on 9 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018), detected; Europe; Personal care - nails - nail polish, and 6 more. Source: EPA CPDat.

Is Butyl methacrylate a carcinogen according to IARC?

Butyl methacrylate is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2023). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Butyl methacrylate used in cosmetics?

Yes, Butyl methacrylate is also indexed as a cosmetic ingredient under the name Butyl Methacrylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Butyl methacrylate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Butyl methacrylate used outside industrial chemicals?

Butyl methacrylate also appears in cosmetics, pharmaceutical, cannabis databases.