Is Butyl Methacrylate safe in cosmetics?
Butyl Methacrylate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 6 toxicological study endpoint(s) are available in our database.
Butyl Methacrylate
Also known as: 2-Propenoic acid, 2-methyl-, butyl ester, BRN 0773960, Butylmethacrylate, EINECS 202-615-1, 2-Methylacrylic acid, butyl ester (+8 more)
INCI: BUTYL METHACRYLATE
Butyl Methacrylate (CAS 97-88-1) is a cosmetic cosmetic ingredient functioning as Film former in nail products; monomer in nail coating systems. NOAEL 30 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 97-88-1 →
Auto-generated CPSR Part A draft with source citations
Function
Film former in nail products; monomer in nail coating systems
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
butyl 2-methylprop-2-enoate
InChIKey
SOGAXMICEFXMKE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Conditional—margin of safety is adequate only when skin contact is avoided. CIR safety conclusion is explicitly conditional on avoidance of skin contact.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyl Methacrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Butyl Methacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =30 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | oral | Rabbit | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =120 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =360 mg/kg bw/day | oral | Rat | repeat dose other | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Pictograms
FlamFlameExcl markWarnCancerHealth haz
Hazard Statements
Flammable liquid and vapour Causes skin and eye irritation May cause an allergic skin reaction May cause respiratory irritation May be harmful if swallowed and enters airways Harmful to aquatic life
Short-term Exposure Effects
Lachrymation. The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. Medical observation is indicated.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Butyl Methacrylate across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
133
Evaluation Year
2023
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 3; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Hazard Statements
- H226 Flammable liquid and vapour
- H335 May cause respiratory irritation
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
Butyl methacrylate | Group 2B: Possibly carcinogenic to humans | Volume 133: (2024) Anthracene, 2-Bromopropane, Butyl Methacrylate, and Dimethyl Hydrogen Phosphite
Source: International Agency for Research on Cancer (IARC)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
1018
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Contact can irritate the eyes and skin. Inhalation can irritate the respiratory tract with coughing, wheezing, and/or shortness of breath. | Irritating to eyes, resp system and skin.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Deodorizer
Film former
Fragrance
Viscosity modifier
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Butyl Methacrylate.
Regulatory Flags
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Butyl Methacrylate by CAS number or substance name.
Studies
24
Lowest NOAEL
30 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
2-Propenoic acid, 2-methyl-, butyl ester
BRN 0773960
Butylmethacrylate
EINECS 202-615-1
2-Methylacrylic acid, butyl ester
2-Methyl-butylacrylate
2-Methyl-butylacrylaat
2-Methyl-butylacrylat
Butil metacrilato
Butylester kyseliny methakrylove
Butylmethacrylaat
Methacrylsaeurebutylester
UNII-R5QX287XXU
Chemical Function
Film former
Deodorizer
Viscosity modifier
Binder
Fragrance
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
detected; Europe; Personal care - nails - nail polish
detected; Europe; Personal care - nails
detected; Europe; Personal care - nails - nail polish
consumer_product; Europe
IFRA Transparency
consumer_product
Europe; nondetect; Other direct contact consumer goods
Europe; nondetect; Other direct contact consumer goods
Cons electronics mech appliances and machinery; detected; Europe
Cons electronics mech appliances and machinery; detected; Europe
Cons electronics mech appliances and machinery; detected; Europe
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
detected; Europe; Personal care - nails - nail polish
detected; Europe; Personal care - nails
detected; Europe; Personal care - nails - nail polish
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183073
Frequently Asked Questions
Is Butyl Methacrylate allowed in the EU?
Butyl Methacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyl Methacrylate do in cosmetics?
Butyl Methacrylate functions as: Film former in nail products; monomer in nail coating systems. It is classified as a cosmetic ingredient in our database. CAS number: 97-88-1.
What is the NOAEL for Butyl Methacrylate?
The NOAEL (No Observed Adverse Effect Level) for Butyl Methacrylate is =30 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 6 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Butyl Methacrylate classified as hazardous under GHS?
Butyl Methacrylate carries a GHS signal word of "WARNING". Hazard statements: Flammable liquid and vapour Causes skin and eye irritation May cause an allergic skin reaction May cause respiratory irritation May be harmful if swallowed and enters airways Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Butyl Methacrylate used outside cosmetics?
Butyl Methacrylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Butyl Methacrylate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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