Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Ethylene glycol dimethacrylate

Also known as: 2-Propenoic acid, 2-methyl-, 1,2-ethanediyl ester, Ageflex EGDM, BRN 1776663, EINECS 202-617-2, UNII-7BK5G69305 (+9 more)

CAS 97-90-5

Ethylene glycol dimethacrylate (CAS 97-90-5) is a chemical substance with GHS signal word Warning; key hazard signal: H335; H317. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Glycol Dimethacrylate →

SOURCE NOAEL studies
NOAEL studies
90
SOURCE Chemical inventory jurisdictions
Regulatory lists
3
SOURCE EU CLP Annex VI
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields
Name
Ethylene glycol dimethacrylate
CAS Number
97-90-5
Molecular Formula
C10H14O4
InChI Key
STVZJERGLQHEKB-UHFFFAOYSA-N
Monoisotopic Mass
198.089209
Synonyms
2-Propenoic acid, 2-methyl-, 1,2-ethanediyl esterAgeflex EGDMBRN 1776663EINECS 202-617-2UNII-7BK5G693051,2-Ethanediyl 2-methyl-2-propenoate2-(Methacryloyloxy)ethyl 2-methylacrylate2-methyl-2-propenoic acid 1,2-ethanediyl esterEGDMAEthyldiol metacrylateEthyldiol methacrylateEthylenedimethyacrylate

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
STOT SE 3; Skin Sens. 1H335; H317GHS07Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records
FieldValue
GHS Signal WordWARNING
GHS Hazard StatementsMay cause an allergic skin reaction Harmful to aquatic life
Long-term EffectsRepeated or prolonged contact may cause skin sensitization.
Routes of ExposureThe substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 13 records
Film formerSoftener and conditionerCatalystHardenerMonomers

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
Europe; Personal care - nailsDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 90 studies
ValueUnitEndpointRouteSpeciesSource
287ug/mLCD54, EC200Dermal-NTP ICE skin sensitization
535.4ug/mLCD54, EC200Dermal-NTP ICE skin sensitization
6.244ug/mLCD86, EC120Dermal-NTP ICE skin sensitization
79.01ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
80.86ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
427ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
>200ug/mLCV70Dermal-NTP ICE skin sensitization
563.6ug/mLCV75Dermal-NTP ICE skin sensitization
1000ug/mLCV75Dermal-NTP ICE skin sensitization
=2.45mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
87.3%Depletion CysDermal-NTP ICE skin sensitization
93.5%Depletion CysDermal-NTP ICE skin sensitization
12.4%Depletion LysDermal-NTP ICE skin sensitization
33.9%Depletion LysDermal-NTP ICE skin sensitization
49.85%Depletion Lys + CysDermal-NTP ICE skin sensitization
63.7%Depletion Lys + CysDermal-NTP ICE skin sensitization
7.06uMEC1.5Dermal-NTP ICE skin sensitization
10.6uMEC1.5Dermal-NTP ICE skin sensitization
12.65uMEC1.5Dermal-NTP ICE skin sensitization
13.32uMEC1.5Dermal-NTP ICE skin sensitization
14uMEC1.5Dermal-NTP ICE skin sensitization
35.56uMEC1.5Dermal-NTP ICE skin sensitization
42uMEC1.5Dermal-NTP ICE skin sensitization
44.45uMEC1.5Dermal-NTP ICE skin sensitization
46.71uMEC1.5Dermal-NTP ICE skin sensitization
47.03uMEC1.5Dermal-NTP ICE skin sensitization
49.74uMEC1.5Dermal-NTP ICE skin sensitization
54.6uMEC1.5Dermal-NTP ICE skin sensitization
54.66uMEC1.5Dermal-NTP ICE skin sensitization
57.41uMEC1.5Dermal-NTP ICE skin sensitization
59.93uMEC1.5Dermal-NTP ICE skin sensitization
67.79uMEC1.5Dermal-NTP ICE skin sensitization
70.31uMEC1.5Dermal-NTP ICE skin sensitization
78.2uMEC1.5Dermal-NTP ICE skin sensitization
81.5uMEC1.5Dermal-NTP ICE skin sensitization
89.3uMEC1.5Dermal-NTP ICE skin sensitization
98.36uMEC1.5Dermal-NTP ICE skin sensitization
112.2uMEC1.5Dermal-NTP ICE skin sensitization
<120.6uMEC1.5Dermal-NTP ICE skin sensitization
123.2uMEC1.5Dermal-NTP ICE skin sensitization
128.5uMEC1.5Dermal-NTP ICE skin sensitization
28%EC3DermalMouseNTP ICE skin sensitization
253.4uMEC3Dermal-NTP ICE skin sensitization
7BK5G69305UNIIFDA UNII substance identifier--openFDA substances
>300uMIC50Dermal-NTP ICE skin sensitization
639.2uMIC50Dermal-NTP ICE skin sensitization
667.4uMIC50Dermal-NTP ICE skin sensitization
783.5uMIC50Dermal-NTP ICE skin sensitization
825.6uMIC50Dermal-NTP ICE skin sensitization
846.2uMIC50Dermal-NTP ICE skin sensitization

Showing 50 of 90 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredEthylene dimethacrylate202-617-2ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL1709582
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Ethylene glycol dimethacrylate?

Ethylene glycol dimethacrylate (CAS 97-90-5) is classified under EU CLP Annex VI as STOT SE 3; Skin Sens. 1 with signal word Warning. Hazard statements: H335; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Ethylene glycol dimethacrylate?

Ethylene glycol dimethacrylate has 90 NOAEL studies in the database. The lowest reported value is 2.45 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.

What regulatory lists include Ethylene glycol dimethacrylate?

Ethylene glycol dimethacrylate appears on 3 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, Indirect additives food contact (10/2018), Europe; Personal care - nails. Source: EPA CPDat.

Is Ethylene glycol dimethacrylate used in cosmetics?

Yes, Ethylene glycol dimethacrylate is also indexed as a cosmetic ingredient under the name Glycol Dimethacrylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ethylene glycol dimethacrylate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Ethylene glycol dimethacrylate have different safety status in cosmetics vs industrial chemicals?

Ethylene glycol dimethacrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H335, H317).

Is Ethylene glycol dimethacrylate used outside industrial chemicals?

Ethylene glycol dimethacrylate also appears in cosmetics, pharmaceutical databases.