Is Glycol Dimethacrylate safe in cosmetics?
Glycol Dimethacrylate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Glycol Dimethacrylate
Also known as: 2-Propenoic acid, 2-methyl-, 1,2-ethanediyl ester, Ageflex EGDM, BRN 1776663, EINECS 202-617-2, UNII-7BK5G69305 (+9 more)
INCI: GLYCOL DIMETHACRYLATE
Glycol Dimethacrylate (CAS 97-90-5) is a cosmetic cosmetic ingredient functioning as Film former; crosslinking monomer. EU Regulation 1223/2009 status: prohibited; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 97-90-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Glycol Dimethacrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H335, H412, H372).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Film former; crosslinking monomer
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(2-methylprop-2-enoyloxy)ethyl 2-methylprop-2-enoate
InChIKey
STVZJERGLQHEKB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no specific CFR cosmetic restriction; no dedicated CIR review as monomer
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glycol Dimethacrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Pictograms
Excl markWarn
Hazard Statements
May cause an allergic skin reaction Harmful to aquatic life
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
STOT SE 3; Skin Sens. 1
Hazard Statements
- H335 May cause respiratory irritation
- H317 May cause an allergic skin reaction
Specific Concentration Limits / M-factors
STOT SE 3; H335: C ≥ 10.0%
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
90.4%
DPRA Lys %
23.15%
KeratinoSens IC50
938.175 µM
hCLAT CV75
781.8 µg/mL
LLNA EC3
28%
NESIL
7000 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Source: LLNA: Gerberick et al. (2005); DPRA: Gerberick et al. 2004 [DOI:10.1093/toxsci/kfh213] | Bauch et al. 2011 [DOI:10.1016/j.tiv.2011.05.030]; KS: Bauch et al. 2011 [DOI:10.1016/j.tiv.2011.05.030] | Joint Research Centre of the European Union 2014; hCLAT: Ashikaga et al. 2010 [DOI:10.1177/026119291003800403] | Bauch et al. 2011 [DOI:10.1016/j.tiv.2011.05.030]
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1270
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritating to eyes & respiratory system.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Catalyst
Film former
Hardener
Monomers
Softener and conditioner
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Glycol Dimethacrylate.
Regulatory Flags
potential-allergen
Known Synonyms
2-Propenoic acid, 2-methyl-, 1,2-ethanediyl ester
Ageflex EGDM
BRN 1776663
EINECS 202-617-2
UNII-7BK5G69305
1,2-Ethanediyl 2-methyl-2-propenoate
2-(Methacryloyloxy)ethyl 2-methylacrylate
2-methyl-2-propenoic acid 1,2-ethanediyl ester
EGDMA
Ethyldiol metacrylate
Ethyldiol methacrylate
Ethylene glycol dimethacrylate
Ethylenedimethyacrylate
Methacrylic acid ethylene ester
Chemical Function
Film former
Softener and conditioner
Catalyst
Hardener
Monomers
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
Indirect additives food contact (10/2018)
Europe; Personal care - nails
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1709582
Frequently Asked Questions
Is Glycol Dimethacrylate allowed in the EU?
Glycol Dimethacrylate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Glycol Dimethacrylate do in cosmetics?
Glycol Dimethacrylate functions as: Film former; crosslinking monomer. It is classified as a cosmetic ingredient in our database. CAS number: 97-90-5.
Is Glycol Dimethacrylate classified as hazardous under GHS?
Glycol Dimethacrylate carries a GHS signal word of "WARNING". Hazard statements: May cause an allergic skin reaction Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Glycol Dimethacrylate used outside cosmetics?
Glycol Dimethacrylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Glycol Dimethacrylate have different safety status in cosmetics vs industrial chemicals?
Glycol Dimethacrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H335, H412, H372).
Compliance Tools
Check Glycol Dimethacrylate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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