What is the NOAEL for 4-tert-Butyltoluene?
4-tert-Butyltoluene has 14 NOAEL studies in the database. The lowest reported value is 589519D43L UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-tert-Butyltoluene
Also known as: Benzene, 1-(1,1-dimethylethyl)-4-methyl-, 4-05-00-01097, BRN 2038670, 1-tert-Butyl-4-methylbenzene, 4-tert-Butyl-1-methylbenzene (+8 more)
CAS 98-51-1
4-tert-Butyltoluene (CAS 98-51-1) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
4-tert-Butyltoluene is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H312, H315, H319, H330, H332, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
4-tert-Butyltoluene
CAS Number
98-51-1
DTXSID
DTXSID1024704
Molecular Formula
C11H16
InChI Key
QCWXDVFBZVHKLV-UHFFFAOYSA-N
Monoisotopic Mass
148.125201
Synonyms
Benzene, 1-(1,1-dimethylethyl)-4-methyl-4-05-00-01097BRN 20386701-tert-Butyl-4-methylbenzene4-tert-Butyl-1-methylbenzenep-t-ButyltolueneEINECS 202-675-9p-Methyl-tert-butylbenzene1-Methyl-4-tert-butylbenzene4-Methyl-tert-butylbenzene8-MethylparacymeneNSC 6589
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Combustible liquid Fatal if inhaled Harmful if swallowed Causes eye irritation May cause damage to central nervous system through prolonged or repeated exposure if inhaled May cause respiratory irritation Toxic to aquatic life |
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. Exposure far above the OEL could cause lowering of consciousness. |
| Long-term Effects | The substance may have effects on the central nervous system. This may result in tissue lesions. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
6 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 10 ppm (60 mg/m³) | 10 | 60 | N |
| NIOSH | TWA | 10 ppm (60 mg/m³) | 10 | 60 | N |
| NIOSH | STEL | 20 ppm (120 mg/m³) | 20 | 120 | N |
| CAL/OSHA | TWA | 1 ppm (6.1 mg/m³) | 1 | 6.1 | N |
| CAL/OSHA | STEL | 20 ppm (120 mg/m³) | 20 | 120 | N |
| NIOSH | IDLH | 100 ppm | 100 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
3 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 589519D43L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 589519D43L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 589519D43L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 589519D43L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.9998 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1555 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =50 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| <150 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =25 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <100 | mg/kg bw/day | NOAEL | oral | Guinea Pig | ToxValDB_ECHA_IUCLID |
| <200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1.5 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =5 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-tert-butyltoluene | 202-675-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1489547
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 4-tert-Butyltoluene?
4-tert-Butyltoluene appears on 2 regulatory/inventory lists including IFRA Transparency, consumer_product. Source: EPA CPDat.
What are the occupational exposure limits for 4-tert-Butyltoluene?
Occupational exposure limits for 4-tert-Butyltoluene are set by OSHA, NIOSH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is 4-tert-Butyltoluene used in cosmetics?
Yes, 4-tert-Butyltoluene is also indexed as a cosmetic ingredient under the name 4-Tert-Butyltoluene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-tert-Butyltoluene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-tert-Butyltoluene have different safety status in cosmetics vs industrial chemicals?
4-tert-Butyltoluene is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H312, H315, H319, H330, H332, H335).
Is 4-tert-Butyltoluene used outside industrial chemicals?
4-tert-Butyltoluene also appears in cosmetics, pharmaceutical databases.