Is 4-Tert-Butyltoluene safe in cosmetics?
4-Tert-Butyltoluene has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
4-Tert-Butyltoluene
Also known as: Benzene, 1-(1,1-dimethylethyl)-4-methyl-, 4-05-00-01097, BRN 2038670, 1-tert-Butyl-4-methylbenzene, 4-tert-Butyl-1-methylbenzene (+8 more)
INCI: 4-TERT-BUTYLTOLUENE
4-Tert-Butyltoluene (CAS 98-51-1) is a cosmetic cosmetic ingredient functioning as Fragrance. Reported NOAEL =25 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 98-51-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
4-Tert-Butyltoluene is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H312, H315, H319, H330, H332, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted; no specific FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Tert-Butyltoluene.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 4-Tert-Butyltoluene. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =25 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
SkullToxicCancerHealth haz
Hazard Statements
Combustible liquid Fatal if inhaled Harmful if swallowed Causes eye irritation May cause damage to central nervous system through prolonged or repeated exposure if inhaled May cause respiratory irritation Toxic to aquatic life
Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract. Exposure far above the OEL could cause lowering of consciousness.
Long-term Exposure Effects
The substance may have effects on the central nervous system. This may result in tissue lesions.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 4-Tert-Butyltoluene.
Regulatory Flags
fragrance-component
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 4-Tert-Butyltoluene by CAS number or substance name.
Studies
4
Lowest NOAEL
25 mg/kg bw/day
Highest NOAEL
25 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Benzene, 1-(1,1-dimethylethyl)-4-methyl-
4-05-00-01097
BRN 2038670
1-tert-Butyl-4-methylbenzene
4-tert-Butyl-1-methylbenzene
p-t-Butyltoluene
EINECS 202-675-9
p-Methyl-tert-butylbenzene
1-Methyl-4-tert-butylbenzene
4-Methyl-tert-butylbenzene
8-Methylparacymene
NSC 6589
UNII-589519D43L
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1489547
Frequently Asked Questions
Is 4-Tert-Butyltoluene allowed in the EU?
4-Tert-Butyltoluene EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Tert-Butyltoluene do in cosmetics?
4-Tert-Butyltoluene functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 98-51-1.
What is the NOAEL for 4-Tert-Butyltoluene?
The NOAEL (No Observed Adverse Effect Level) for 4-Tert-Butyltoluene is =25 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is 4-Tert-Butyltoluene classified as hazardous under GHS?
4-Tert-Butyltoluene carries a GHS signal word of "DANGER". Hazard statements: Combustible liquid Fatal if inhaled Harmful if swallowed Causes eye irritation May cause damage to central nervous system through prolonged or repeated exposure if inhaled May cause respiratory irritation Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is 4-Tert-Butyltoluene used outside cosmetics?
4-Tert-Butyltoluene also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 4-Tert-Butyltoluene have different safety status in cosmetics vs industrial chemicals?
4-Tert-Butyltoluene is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H312, H315, H319, H330, H332, H335).
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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