4-Tert-Butyltoluene
INCI: 4-TERT-BUTYLTOLUENE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 4-Tert-Butyltoluene. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 1.5 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Moderately toxic by inhalation with testicular atrophy and Leydig cell hyperplasia at ≥50 mg/kg/day in rats; chronic inhalation causes neurotoxic lesions including demyelination and encephalomeningitis with NOAEL of 1.67 mg/kg/day.
Regulatory Flags
Frequently Asked Questions
Is 4-Tert-Butyltoluene safe in cosmetics?
Moderately toxic by inhalation with testicular atrophy and Leydig cell hyperplasia at ≥50 mg/kg/day in rats; chronic inhalation causes neurotoxic lesions including demyelination and encephalomeningitis with NOAEL of 1.67 mg/kg/day. The EU classifies 4-Tert-Butyltoluene as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is 4-Tert-Butyltoluene allowed in the EU?
4-Tert-Butyltoluene EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Tert-Butyltoluene do in cosmetics?
4-Tert-Butyltoluene functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 98-51-1.
What is the Margin of Safety for 4-Tert-Butyltoluene?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 4-Tert-Butyltoluene?
The NOAEL (No Observed Adverse Effect Level) for 4-Tert-Butyltoluene is 1.5 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Is 4-Tert-Butyltoluene classified as hazardous under GHS?
4-Tert-Butyltoluene carries a GHS signal word of "DANGER". Hazard statements: Combustible liquid Fatal if inhaled Harmful if swallowed Causes eye irritation May cause damage to central nervous system through prolonged or repeated exposure if inhaled May cause respiratory irritation Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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