NOAEL Data REACH Registered Cosmetic Ingredient

4-tert-Butylcyclohexanol

Also known as: Cyclohexanol, 4-(1,1-dimethylethyl)-, 1-06-00-00018, BRN 1902277, p-tert-Butylcyclohexanol, EINECS 202-676-4 (+3 more)

CAS 98-52-2

4-tert-Butylcyclohexanol (CAS 98-52-2) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for 4-T-Butylcyclohexanol →

Cross-Vertical Regulatory Divergence

4-tert-Butylcyclohexanol is prohibited in EU cosmetics but has active industrial GHS classifications (H319).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields

Name

4-tert-Butylcyclohexanol

CAS Number

98-52-2

Molecular Formula

C10H20O

InChI Key

CCOQPGVQAWPUPE-UHFFFAOYSA-N

Monoisotopic Mass

156.151415

Synonyms

Cyclohexanol, 4-(1,1-dimethylethyl)-1-06-00-00018BRN 1902277p-tert-ButylcyclohexanolEINECS 202-676-4NSC 404197PadarylUNII-K0H1405S9C

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 20 records

FragranceDeodorizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records

List	Keyword	Source
Arts and crafts/Office supplies - fabric treatment and dye; detected	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions	Elsevier	CPCat
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
consumer_product	P&G	Proctor & Gamble
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies

Value	Unit	Endpoint	Route	Species	Source
=0.025	mg/kg bw/day	ADI	-	Consumers	EFSA
=0.03	mg/kg bw/day	ADI	-	Consumers	EFSA
=0.1	mg/kg bw	ARfD	-	Consumers	EFSA
=0.1	mg/kg bw/day	ARfD	-	Consumers	EFSA
=1.76	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
=4.93	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
K0H1405S9C	UNII	FDA UNII substance identifier	-	-	openFDA substances
0	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
2592	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
>2000	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=4200	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=300	mg/kg bw/day	LOAEL	oral	Rat	ECHA
0	unitless	Model Score	-	-	NTP ICE endocrine
=2.5	mg/kg bw/day	NOAEL	oral: unspecified	Dog	EFSA
=10	mg/kg bw/day	NOAEL	-	Rat	EFSA
=30	mg/kg bw/day	NOAEL	oral	Rat	EFSA
=30	mg/kg bw/day	NOAEL	-	Rat	EFSA
=31.5	mg/kg bw/day	NOAEL	oral	Rat	EFSA
=31.5	mg/kg bw/day	NOAEL	-	Rat	EFSA
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB HPVIS
=150	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=2.02	mg/kg bw/day	NOEL	-	Bobwhite quail	EFSA
=9.19	mg/kg bw/day	NOEL	-	Rat	EFSA
=10.6	mg/kg bw/day	NOEL	-	Mallard duck	EFSA
=22.2	mg/kg bw/day	NOEL	-	Rat	EFSA
3	unitless	Relative reliability score	Dermal	Human	NTP ICE skin sensitization

Showing 26 of 26 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	4-tert-butylcyclohexanol	202-676-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 4-tert-Butylcyclohexanol?

4-tert-Butylcyclohexanol has 26 NOAEL studies in the database. The lowest reported value is 0.025 mg/kg bw/day in Consumers. Source: EFSA.

What regulatory lists include 4-tert-Butylcyclohexanol?

4-tert-Butylcyclohexanol appears on 6 regulatory/inventory lists including Arts and crafts/Office supplies - fabric treatment and dye; detected, air; Cleaning products and household care - air freshener; detected; emissions, air; Cleaning products and household care - air freshener; detected; emissions; Europe, and 3 more. Source: EPA CPDat.

Is 4-tert-Butylcyclohexanol used in cosmetics?

Yes, 4-tert-Butylcyclohexanol is also indexed as a cosmetic ingredient under the name 4-T-Butylcyclohexanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-tert-Butylcyclohexanol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-tert-Butylcyclohexanol have different safety status in cosmetics vs industrial chemicals?

4-tert-Butylcyclohexanol is prohibited in EU cosmetics but has active industrial GHS classifications (H319).

Is 4-tert-Butylcyclohexanol used outside industrial chemicals?

4-tert-Butylcyclohexanol also appears in cosmetics, cannabis databases.