Is 4-T-Butylcyclohexanol safe in cosmetics?
4-T-Butylcyclohexanol has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
4-T-Butylcyclohexanol
Also known as: Cyclohexanol, 4-(1,1-dimethylethyl)-, 1-06-00-00018, BRN 1902277, p-tert-Butylcyclohexanol, EINECS 202-676-4 (+3 more)
INCI: 4-T-BUTYLCYCLOHEXANOL
4-T-Butylcyclohexanol (CAS 98-52-2) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient / solvent. NOAEL 150 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 98-52-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
4-T-Butylcyclohexanol is prohibited in EU cosmetics but has active industrial GHS classifications (H319).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient / solvent
Safety Rating
GOOD
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted; no specific FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-T-Butylcyclohexanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for 4-T-Butylcyclohexanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =2.5 mg/kg bw/day | oral: unspecified | Dog | chronic/long term toxicity | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| NOAEL | =10 mg/kg bw/day | - | Rat | acute toxicity | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| NOAEL | =150 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 4-T-Butylcyclohexanol across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 4-T-Butylcyclohexanol.
Regulatory Flags
fragrance-component
endocrine_disruptor
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 4-T-Butylcyclohexanol by CAS number or substance name.
Studies
3
Lowest NOAEL
2.5 mg/kg bw/day
Highest NOAEL
150 mg/kg bw/day
ToxValDB_ECHA_IUCLID
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Known Synonyms
Cyclohexanol, 4-(1,1-dimethylethyl)-
1-06-00-00018
BRN 1902277
p-tert-Butylcyclohexanol
EINECS 202-676-4
NSC 404197
Padaryl
UNII-K0H1405S9C
Chemical Function
Fragrance
Deodorizer
Regulatory Lists
Arts and crafts/Office supplies - fabric treatment and dye; detected
air; Cleaning products and household care - air freshener; detected; emissions
air; Cleaning products and household care - air freshener; detected; emissions; Europe
IFRA Transparency
consumer_product
inert_ingredient; non_food_use; Pesticides
air; Cleaning products and household care - air freshener; detected; emissions; Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 4-T-Butylcyclohexanol allowed in the EU?
4-T-Butylcyclohexanol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-T-Butylcyclohexanol do in cosmetics?
4-T-Butylcyclohexanol functions as: Fragrance ingredient / solvent. It is classified as a cosmetic ingredient in our database. CAS number: 98-52-2.
What is the NOAEL for 4-T-Butylcyclohexanol?
The NOAEL (No Observed Adverse Effect Level) for 4-T-Butylcyclohexanol is =2.5 mg/kg bw/day based on a chronic/long term toxicity study via oral: unspecified route in Dog. A total of 3 study endpoints are available. Source: EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx.
Is 4-T-Butylcyclohexanol used outside cosmetics?
4-T-Butylcyclohexanol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 4-T-Butylcyclohexanol have different safety status in cosmetics vs industrial chemicals?
4-T-Butylcyclohexanol is prohibited in EU cosmetics but has active industrial GHS classifications (H319).
Compliance Tools
Check 4-T-Butylcyclohexanol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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