What is the NOAEL for 4-tert-Butylcyclohexanone?
4-tert-Butylcyclohexanone has 11 NOAEL studies in the database. The lowest reported value is 4M45G11K23 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-tert-Butylcyclohexanone
Also known as: Cyclohexanone, 4-(1,1-dimethylethyl)-, 4-07-00-00082, BRN 0507309, EINECS 202-678-5
CAS 98-53-3
4-tert-Butylcyclohexanone (CAS 98-53-3) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for 4-Tert-Butylcyclohexanone →
Cross-Vertical Regulatory Divergence
4-tert-Butylcyclohexanone is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
4-tert-Butylcyclohexanone
CAS Number
98-53-3
DTXSID
DTXSID7044394
Molecular Formula
C10H18O
InChI Key
YKFKEYKJGVSEIX-UHFFFAOYSA-N
Monoisotopic Mass
154.135765
Synonyms
Cyclohexanone, 4-(1,1-dimethylethyl)-4-07-00-00082BRN 0507309EINECS 202-678-5
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 4M45G11K23 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4M45G11K23 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4M45G11K23 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4M45G11K23 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3888 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >300 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-tert-butylcyclohexanone | 202-678-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3188541
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 4-tert-Butylcyclohexanone?
4-tert-Butylcyclohexanone appears on 2 regulatory/inventory lists including IFRA Transparency, consumer_product. Source: EPA CPDat.
Is 4-tert-Butylcyclohexanone used in cosmetics?
Yes, 4-tert-Butylcyclohexanone is also indexed as a cosmetic ingredient under the name 4-Tert-Butylcyclohexanone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-tert-Butylcyclohexanone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-tert-Butylcyclohexanone have different safety status in cosmetics vs industrial chemicals?
4-tert-Butylcyclohexanone is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H411).
Is 4-tert-Butylcyclohexanone used outside industrial chemicals?
4-tert-Butylcyclohexanone also appears in cosmetics, pharmaceutical databases.