Is 4-Tert-Butylcyclohexanone safe in cosmetics?
4-Tert-Butylcyclohexanone has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted.
Good
Cosmetic Ingredient
4-Tert-Butylcyclohexanone
Also known as: Cyclohexanone, 4-(1,1-dimethylethyl)-, 4-07-00-00082, BRN 0507309, EINECS 202-678-5
INCI: 4-TERT-BUTYLCYCLOHEXANONE
4-Tert-Butylcyclohexanone (CAS 98-53-3) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 98-53-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
4-Tert-Butylcyclohexanone is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H411).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
EC Number
202-678-5
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted; no specific FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Tert-Butylcyclohexanone.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3888 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
IFRA Concentration Limits (12 Product Categories)
International Fragrance Association standards per product category. Restriction: Restriction. Effective: 2024-01-01.
| Category | Max % | Category | Max % |
|---|---|---|---|
| 1 (Lip products) | – | 7a (Deodorant – not spray) | – |
| 2 (Body spray) | – | 7b (Deodorant spray) | – |
| 3 (Body cream) | – | 8 (Face cream) | – |
| 4 (Fine fragrance) | – | 9 (Soap) | – |
| 5a (Body lotion) | – | 10a (Household – non-spray) | – |
| 5b (Face cream leave-on) | – | 10b (Household – spray) | – |
| 5c (Hand cream) | – | 11a (Intimate – leave-on) | – |
| 5d (Baby cream) | – | 11b (Intimate – rinse) | – |
| 6 (Mouthwash) | – | 12 (Not for consumer exposure) | – |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 4-Tert-Butylcyclohexanone.
Regulatory Flags
fragrance-component
ifra_fragrance
Known Synonyms
Cyclohexanone, 4-(1,1-dimethylethyl)-
4-07-00-00082
BRN 0507309
EINECS 202-678-5
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188541
Frequently Asked Questions
Is 4-Tert-Butylcyclohexanone allowed in the EU?
4-Tert-Butylcyclohexanone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Tert-Butylcyclohexanone do in cosmetics?
4-Tert-Butylcyclohexanone functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 98-53-3.
Is 4-Tert-Butylcyclohexanone used outside cosmetics?
4-Tert-Butylcyclohexanone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 4-Tert-Butylcyclohexanone have different safety status in cosmetics vs industrial chemicals?
4-Tert-Butylcyclohexanone is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H411).
Compliance Tools
Check 4-Tert-Butylcyclohexanone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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