What is the NOAEL for Pidolic acid?
Pidolic acid has 6 NOAEL studies in the database. The lowest reported value is 6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Pidolic acid
Also known as: AJIDEW A-100, 2-Benzothiazolesulfenic acid morpholide, EINECS 202-700-3, L-Glutamic acid gamma-lactam, 2-Oxopyrrolidine-5-carboxylic acid (+10 more)
CAS 98-79-3
Pidolic acid (CAS 98-79-3) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Pidolic acid is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Pidolic acid
CAS Number
98-79-3
DTXSID
DTXSID6046260
Molecular Formula
C5H7NO3
InChI Key
ODHCTXKNWHHXJC-VKHMYHEASA-N
Monoisotopic Mass
129.042593
Synonyms
AJIDEW A-1002-Benzothiazolesulfenic acid morpholideEINECS 202-700-3L-Glutamic acid gamma-lactam2-Oxopyrrolidine-5-carboxylic acidProline, 5-oxo-2-Pyrrolidone-5-carboxylateNSC 9966Acidum pidolicumUNII-SZB83O1W425-L-OxoprolinePidolate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
HumectantFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| SZB83O1W42 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SZB83O1W42 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SZB83O1W42 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SZB83O1W42 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Pidolic acid | 202-700-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Humectants
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PIDOLIC ACID
ChEMBL Phase
2
Adverse Events
0
Bioactivity
4
Frequently Asked Questions
What regulatory lists include Pidolic acid?
Pidolic acid appears on 3 regulatory/inventory lists including Europe, pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Pidolic acid used in cosmetics?
Yes, Pidolic acid is also indexed as a cosmetic ingredient under the name PCA. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Pidolic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Pidolic acid have different safety status in cosmetics vs industrial chemicals?
Pidolic acid is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is Pidolic acid used outside industrial chemicals?
Pidolic acid also appears in cosmetics, pharmaceutical databases.