What is the NOAEL for 3,4-Dihydroxybenzoic acid?
3,4-Dihydroxybenzoic acid has 4 NOAEL studies in the database. The lowest reported value is 36R5QJ8L4B UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
3,4-Dihydroxybenzoic acid
Also known as: Protocatechuic acid, BRN 1448841, EINECS 202-760-0, UNII-36R5QJ8L4B, 2,4-Dihydroxybenzoate (+7 more)
CAS 99-50-3
3,4-Dihydroxybenzoic acid (CAS 99-50-3) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
3,4-Dihydroxybenzoic acid
CAS Number
99-50-3
DTXSID
DTXSID4021212
Molecular Formula
C7H6O4
InChI Key
YQUVCSBJEUQKSH-UHFFFAOYSA-N
Monoisotopic Mass
154.026609
Synonyms
Protocatechuic acidBRN 1448841EINECS 202-760-0UNII-36R5QJ8L4B2,4-Dihydroxybenzoate2,4-Dihydroxybenzoic acid3,4-DihydroxybenzoateProtocatehuic acidb-Resorcylateb-Resorcylic acidbeta-Resorcylic acidbeta-resorcylate
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
2 records
HumectantFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 36R5QJ8L4B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 36R5QJ8L4B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 36R5QJ8L4B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 36R5QJ8L4B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
PROTOCATECHUIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
10
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 3,4-Dihydroxybenzoic acid?
3,4-Dihydroxybenzoic acid appears on 1 regulatory/inventory list including food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 3,4-Dihydroxybenzoic acid used in cosmetics?
Yes, 3,4-Dihydroxybenzoic acid is also indexed as a cosmetic ingredient under the name Protocatechuic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3,4-Dihydroxybenzoic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 3,4-Dihydroxybenzoic acid used outside industrial chemicals?
3,4-Dihydroxybenzoic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.