Protocatechuic Acid

INCI: PROTOCATECHUIC ACID

CAS Number
99-50-3
Function
Antioxidant, Skin Conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not restricted by FDA; not specifically reviewed as a standalone ingredient by CIR; recognized metabolite of dietary polyphenols

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

At high concentrations can inhibit melanogenesis (relevant for claims but not a safety hazard); no CMR classification

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Concern Level: Low

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Protocatechuic Acid safe in cosmetics?

At high concentrations can inhibit melanogenesis (relevant for claims but not a safety hazard); no CMR classification The EU classifies Protocatechuic Acid as "permitted". Safety rating: GOOD.

Is Protocatechuic Acid allowed in the EU?

Protocatechuic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Protocatechuic Acid do in cosmetics?

Protocatechuic Acid functions as: Antioxidant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 99-50-3.

What is the Margin of Safety for Protocatechuic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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