What is the NOAEL for 4-Nitro-1,2-phenylenediamine?
4-Nitro-1,2-phenylenediamine has 65 NOAEL studies in the database. The lowest reported value is 0.042 mg/kg via oral in rat. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
NOAEL Data
IARC Group 3
Cosmetic Ingredient
4-Nitro-1,2-phenylenediamine
Also known as: 4-Nitro-o-phenylenediamine, 4-13-00-00075, BRN 0608106, EINECS 202-766-3, NCI-C03941 (+8 more)
CAS 99-56-9
4-Nitro-1,2-phenylenediamine (CAS 99-56-9) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ILO ICSC.
View cosmetic safety profile for 4-Nitro-O-Phenylenediamine →
SOURCE
noael studies public
NOAEL studies
65
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
4-Nitro-1,2-phenylenediamine
CAS Number
99-56-9
DTXSID
DTXSID9020958
Molecular Formula
C6H7N3O2
InChI Key
RAUWPNXIALNKQM-UHFFFAOYSA-N
Monoisotopic Mass
153.053826
Synonyms
4-Nitro-o-phenylenediamine4-13-00-00075BRN 0608106EINECS 202-766-3NCI-C039414-Nitro-para-phenylenediamine4-Nitrophenylenediamine4-Nitro-o-phenylene-diamine4-Nitro-1,2-fenylendiaminNitro-o-phenylenediamineUNII-5A9AX7Y0TTp-nitro-o-phenylendiamine
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 16, Sup 7 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 65 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 15 | mg/kg bw/day | - | oral | dog | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 45 | mg/kg/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 45 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 45 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 45 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 500 | mg/kg | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 500 | mg/kg | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 5A9AX7Y0TT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5A9AX7Y0TT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5A9AX7Y0TT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5A9AX7Y0TT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =0.042 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.042 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.042 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.042 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw/d | NOAEL | dermal | rat | CIR_vision_codex |
| =15 | mg/kg bw/day | NOAEL | oral | dog | SCCS_vision_codex |
| =15 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw/d | NOAEL | dermal | rat | CIR_vision_codex |
| =15 | mg/kg bw/d | NOAEL | dermal | rat | CIR_vision_codex |
| =15 | mg/kg bw/day | NOAEL | oral | dog | SCCS_vision_codex |
| =15 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw/day | NOAEL | oral | dog | SCCS_vision_codex |
| =15 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw/d | NOAEL | dermal | rat | CIR_vision_codex |
| =15 | mg/kg bw/day | NOAEL | oral | dog | SCCS_vision_codex |
| =15 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =45 | mg/kg bw/d | NOAEL | dermal | rat | CIR_vision_codex |
| =45 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =45 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =45 | mg/kg bw/d | NOAEL | dermal | rat | CIR_vision_codex |
| =45 | mg/kg bw/d | NOAEL | dermal | rat | CIR_vision_codex |
| =45 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =45 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =45 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =45 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =45 | mg/kg bw/d | NOAEL | dermal | rat | CIR_vision_codex |
| =45 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =45 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =65 | % | NOAEL | oral | - | SCCS_vision_codex |
| =65 | % | NOAEL | oral | - | SCCS_vision_codex |
| =65 | % | NOAEL | oral | - | SCCS_vision_codex |
| =65 | % | NOAEL | oral | - | SCCS_vision_codex |
| =265 | mg/kg/day | NOAEL | - | - | SCCS_vision_codex |
| =265 | mg/kg/day | NOAEL | - | - | SCCS_vision_codex |
| =265 | mg/kg/day | NOAEL | - | - | SCCS_vision_codex |
Showing 50 of 65 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1006/06 | 19 December 2006 | not safe | - | genotoxicity; low MoS |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL433721
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 4-Nitro-1,2-phenylenediamine?
4-Nitro-1,2-phenylenediamine appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.
Is 4-Nitro-1,2-phenylenediamine a carcinogen according to IARC?
4-Nitro-1,2-phenylenediamine is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is 4-Nitro-1,2-phenylenediamine used in cosmetics?
Yes, 4-Nitro-1,2-phenylenediamine is also indexed as a cosmetic ingredient under the name 4-Nitro-O-Phenylenediamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Nitro-1,2-phenylenediamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-Nitro-1,2-phenylenediamine used outside industrial chemicals?
4-Nitro-1,2-phenylenediamine also appears in cosmetics, pharmaceutical databases.