4-Nitro-O-Phenylenediamine
INCI: 4-NITRO-O-PHENYLENEDIAMINE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Sensitization Profile
Contact sensitization data for 4-Nitro-O-Phenylenediamine based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Expert Verdict
Restricted under Annex III with concentration limits and mandatory labeling. Must include allergic reaction warning. Not for use on eyebrows or eyelashes.
Regulatory Flags
Frequently Asked Questions
Is 4-Nitro-O-Phenylenediamine safe in cosmetics?
Restricted under Annex III with concentration limits and mandatory labeling. Must include allergic reaction warning. Not for use on eyebrows or eyelashes. The EU classifies 4-Nitro-O-Phenylenediamine as "restricted". Safety rating: MODERATE.
Is 4-Nitro-O-Phenylenediamine allowed in the EU?
4-Nitro-O-Phenylenediamine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Nitro-O-Phenylenediamine do in cosmetics?
4-Nitro-O-Phenylenediamine functions as: Hair colorant used in both oxidative (permanent) and direct (semi-permanent) dye formulations. It is classified as a cosmetic ingredient in our database. CAS number: 99-56-9.
What is the Margin of Safety for 4-Nitro-O-Phenylenediamine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check 4-Nitro-O-Phenylenediamine compliance across multiple jurisdictions:
Related Ingredients
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