Also known as: 1-Methyl-4-(propan-2-yl)cyclohexa-1,3-diene, 1,3-Cyclohexadiene, 1-methyl-4-isopropyl-, EINECS 202-795-1, FEMA No. 3558, alpha-Terpinen (+8 more)
CAS 99-86-5
Alpha-Terpinene (CAS 99-86-5) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H302; H304; H317; H411. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Alpha-Terpinene is classified GHS Danger (H226, H302, H304, H317, H411) in the chemicals database but is restricted in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Acute Tox. 4; Asp. Tox. 1; Skin Sens. 1; Aquatic Chronic 2 | H226; H302; H304; H317; H411 | GHS02; GHS07; GHS08; GHS09 | Danger |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; consumer_product; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; Cleaning products and household care; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care - air freshener; detected; emissions | Elsevier | CPCat |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 30.97 | uM | AC50 | - | - | NTP ICE endocrine |
| 20.04 | uM | ACC | - | - | NTP ICE endocrine |
| =2.939 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 8.9 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| I24X278AP1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 3240 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =1680 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0161 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0482 | unitless | Model Score | - | - | NTP ICE endocrine |
| =30 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 60 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 14 of 14 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | p-mentha-1,3-diene | 202-795-1 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Alpha-Terpinene (CAS 99-86-5) is classified under EU CLP Annex VI as Flam. Liq. 3; Acute Tox. 4; Asp. Tox. 1; Skin Sens. 1; Aquatic Chronic 2 with signal word Danger. Hazard statements: H226; H302; H304; H317; H411. Source: EU CLP Annex VI (ECHA).
Alpha-Terpinene has 14 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
Alpha-Terpinene appears on 10 regulatory/inventory lists including Europe; Personal care; restricted, inert_ingredient; non_food_use; Pesticides, air; consumer_product; detected; emissions, and 7 more. Source: EPA CPDat.
Yes, Alpha-Terpinene is also indexed as a cosmetic ingredient under the name Alpha-Terpinene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Alpha-Terpinene is classified GHS Danger (H226, H302, H304, H317, H411) in the chemicals database but is restricted in EU cosmetics.
Alpha-Terpinene also appears in cosmetics, pharmaceutical, cannabis databases.