Also known as: UNII-KZ27KOJ0GZ, 2-((2-Hydroxyethyl)amino)-4,6-dinitrophenol, Phenol, 2-((2-hydroxyethyl)amino)-4,6-dinitro-
CAS 99610-72-7
2-Hydroxyethyl picramic acid (CAS 99610-72-7) is a chemical substance with GHS signal word Warning; key hazard signal: H228; H361f ***; H302. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for 2-Hydroxyethyl Picramic Acid →
2-Hydroxyethyl picramic acid is classified GHS CMR hazard (H228, H361f, H302) in the chemicals database but is restricted in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Sol. 2; Repr. 2; Acute Tox. 4 * | H228; H361f ***; H302 | GHS02; GHS08; GHS07 | Warning |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 20 | mg/kg bw | - | - | rat | Regulatory source |
| 50 | mg/kg bw/day | - | - | human | Regulatory source |
| KZ27KOJ0GZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 20 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =0.13 | mg/kg bw | NOAEL | oral | rat | SCCS Opinion |
| =0.16 | mg/kg bw | NOAEL | oral | rat | SCCS Opinion |
| =15 | mg/kg bw | NOAEL | - | rat | SCCS Opinion |
| =20 | mg/kg bw | NOAEL | - | rat | SCCS Opinion |
| =20 | mg/kg bw/day | NOAEL | - | rat | SCCS Opinion |
| =50 | mg/kg bw | NOAEL | oral | - | SCCS Opinion |
| =50 | mg/kg bw/day | NOAEL | - | human | SCCS Opinion |
| =60 | mg/kg bw | NOAEL | - | rat | SCCS Opinion |
| =120 | mg/kg bw/day | NOAEL | oral | rat | SCCS Opinion |
| =120 | mg/kg bw | NOAEL | dermal | rabbit | SCCS Opinion |
| =0.13 | mg/kg bw | dermal absorption | oral | rat | Regulatory source |
| =0.16 | mg/kg bw | dermal absorption | oral | rat | Regulatory source |
| =20 | mg/kg bw | dermal absorption | oral | rat | Regulatory source |
| 15 | mg/kg bw | genotoxicity | - | rat | Regulatory source |
| 50 | mg/kg bw | repeated dose toxicity | oral | - | Regulatory source |
| 20 | mg/kg bw/day | reproductive toxicity | - | rat | Regulatory source |
| 50 | mg/kg bw/day | reproductive toxicity | - | rat | Regulatory source |
| 60 | mg/kg bw | reproductive toxicity | - | rat | Regulatory source |
| 120 | mg/kg bw/day | reproductive toxicity | oral | rat | Regulatory source |
| 120 | mg/kg bw | reproductive toxicity | dermal | rabbit | Regulatory source |
| 120 | mg/kg bw | reproductive toxicity | - | rabbit | Regulatory source |
Showing 25 of 25 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(2-hydroxy-3,5-dinitroanilino)ethanol | 412-520-9 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1058/06 | 2007-06-19 | The SCCP is of the opinion that the information submitted is insufficient to allow a final risk assessment to be carried out. Before any further consideration, the possible genotoxic potential must be excluded. | - | Possible genotoxic potential must be excluded before further consideration; secondary amine - should not be used with nitrosating substances, nitrosamine content < 50 ppb; classified toxic to reproduction category 3 (R62) based on BgVV 1993 testes atrophy finding, though more recent studies do not support this classification. |
| SCCP/1208/08 | 2008-12-16 | The SCCP is of the opinion that the use of 2-Hydroxyethylpicramic acid as an ingredient in non-oxidative hair dye formulations with a maximum on-head concentration of 2.0% and in oxidative hair dye formulations with a maximum on-head concentration of 1.5% does not pose a risk to the health of the consumer. | 2.0% on-head (non-oxidative); 1.5% on-head (oxidative) | Secondary amine - should not be used in combination with nitrosating substances; nitrosamine content should be < 50 ppb. Previously classified toxic to reproduction category 3 (R62), though more recent studies do not support this classification. |
Same-CAS cosmetic ingredient record for cross-vertical context.
2-Hydroxyethyl picramic acid (CAS 99610-72-7) is classified under EU CLP Annex VI as Flam. Sol. 2; Repr. 2; Acute Tox. 4 * with signal word Warning. Hazard statements: H228; H361f ***; H302. Source: EU CLP Annex VI (ECHA).
2-Hydroxyethyl picramic acid has 25 NOAEL studies in the database. The lowest reported value is 20 mg/kg bw in rat. Source: Regulatory source.
2-Hydroxyethyl picramic acid appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring. Source: EPA CPDat.
Yes, 2-Hydroxyethyl picramic acid is also indexed as a cosmetic ingredient under the name 2-Hydroxyethyl Picramic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
2-Hydroxyethyl picramic acid is classified GHS CMR hazard (H228, H361f, H302) in the chemicals database but is restricted in EU cosmetics.
2-Hydroxyethyl picramic acid also appears in cosmetics databases.