Is 2-Hydroxyethyl Picramic Acid safe in cosmetics?
2-Hydroxyethyl Picramic Acid has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2-Hydroxyethyl Picramic Acid
Also known as: UNII-KZ27KOJ0GZ, 2-((2-Hydroxyethyl)amino)-4,6-dinitrophenol, Phenol, 2-((2-hydroxyethyl)amino)-4,6-dinitro-
INCI: 2-HYDROXYETHYL PICRAMIC ACID
2-Hydroxyethyl Picramic Acid (CAS 99610-72-7) is a cosmetic cosmetic ingredient functioning as Hair dyeing — semi-permanent/temporary direct dye. Reported NOAEL =0.13 mg/kg bw in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 99610-72-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Hydroxyethyl Picramic Acid is classified GHS Danger (H228, H302, H361, H361f) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing — semi-permanent/temporary direct dye
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-(2-hydroxyethylamino)-4,6-dinitrophenol
InChIKey
OABRBVCUJIJMOB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted; listed in VCRP for hair colorant use; no specific FDA restriction beyond general safety requirements
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Hydroxyethyl Picramic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 2-Hydroxyethyl Picramic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.13 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.13 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.13 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.13 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.16 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.16 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.16 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.16 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =15 mg/kg bw | - | rat | genotoxicity | SCCS_vision_codex |
| NOAEL | =15 mg/kg bw | - | rat | genotoxicity | SCCS_vision_codex |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
FlammableHealth HazardHarmful / Irritant
Hazard Class and Category
Flam. Sol. 2; Repr. 2; Acute Tox. 4 *
Hazard Statements
- H228 Flammable solid
- H361f ***
- H302 Harmful if swallowed
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair day products (b) Hair dye substance in non-oxidative hair day products. Max: (b) 2.0%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 2.0%
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (2 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 1.384% | - | - | SCCP/1058/06 |
| measured_sccs_opinion | 1.384% | - | - | SCCP/1058/06 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2-Hydroxyethyl Picramic Acid.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-Hydroxyethyl Picramic Acid by CAS number or substance name.
Studies
40
Lowest NOAEL
0.13
Highest NOAEL
120
Units vary across source rows: mg/kg bw, mg/kg bw/day
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 1.384% | SCCS opinion extraction | - |
| 1.384% | SCCS opinion extraction | - |
Known Synonyms
UNII-KZ27KOJ0GZ
2-((2-Hydroxyethyl)amino)-4,6-dinitrophenol
Phenol, 2-((2-hydroxyethyl)amino)-4,6-dinitro-
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Canada; Personal care; Substances in PCP - Canada (4/2014)
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 2-Hydroxyethyl Picramic Acid allowed in the EU?
2-Hydroxyethyl Picramic Acid EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Hydroxyethyl Picramic Acid do in cosmetics?
2-Hydroxyethyl Picramic Acid functions as: Hair dyeing — semi-permanent/temporary direct dye. It is classified as a cosmetic ingredient in our database. CAS number: 99610-72-7.
What is the NOAEL for 2-Hydroxyethyl Picramic Acid?
The NOAEL (No Observed Adverse Effect Level) for 2-Hydroxyethyl Picramic Acid is =0.13 mg/kg bw based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is 2-Hydroxyethyl Picramic Acid used outside cosmetics?
2-Hydroxyethyl Picramic Acid also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Hydroxyethyl Picramic Acid have different safety status in cosmetics vs industrial chemicals?
2-Hydroxyethyl Picramic Acid is classified GHS Danger (H228, H302, H361, H361f) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check 2-Hydroxyethyl Picramic Acid compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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