GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

HC Blue 14

CAS 99788-75-7

HC Blue 14 (CAS 99788-75-7) is a chemical substance; key hazard signal: H411. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH.

View cosmetic safety profile for HC Blue No. 14 →

SOURCE noael studies public
NOAEL studies
41
SOURCE chemical inventory jurisdictions
Regulatory lists
1
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields
Name
HC Blue 14
CAS Number
99788-75-7
DTXSID
DTXSID40879813
Molecular Formula
C20H22N2O6
InChI Key
AQNZDXHBYRTSHA-UHFFFAOYSA-N
Monoisotopic Mass
386.147786

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Aquatic Chronic 2H411GHS09-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 41 of 41 studies
ValueUnitEndpointRouteSpeciesSource
UVQ553995FUNIIFDA UNII substance identifier--openFDA substances
UVQ553995FUNIIFDA UNII substance identifier--openFDA substances
UVQ553995FUNIIFDA UNII substance identifier--openFDA substances
UVQ553995FUNIIFDA UNII substance identifier--openFDA substances
50mg/kg bw/dayLOAELoralratCOSMOS_DB
=0.0008mg/kg bwNOAELoralratSCCS_vision_codex
=0.0008mg/kg bwNOAELoralratSCCS_vision_codex
=0.0008mg/kg bwNOAELoralratSCCS_vision_codex
=0.0008mg/kg bwNOAELoralratSCCS_vision_codex
=50%NOAELoralratSCCS_vision_codex
=50%NOAELoralratSCCS_vision_codex
=50%NOAELoralratSCCS_vision_codex
=50%NOAELoralratSCCS_vision_codex
=500mg/kg bw/dNOAELoralratSCCS_vision_codex
=500mg/kg bw/dNOAELoralratSCCS_vision_codex
=500mg/kg bw/dNOAELoralratSCCS_vision_codex
=500mg/kg bw/dNOAELoralratSCCS_vision_codex
=1000mg/kg bw/dayNOAEL--SCCS_vision_codex
=1000mg/kg bw/dNOAELoralratSCCS_vision_codex
=1000mg/kg/dayNOAELdermal-SCCNFP_vision_codex
=1000mg/kg bw/dayNOAEL--SCCS_vision_codex
=1000mg/kg bw/dNOAELoralratSCCS_vision_codex
=1000mg/kg bw/dayNOAEL--SCCS_vision_codex
=1000mg/kg bw/dNOAELoralratSCCS_vision_codex
=1000mg/kg/dayNOAELdermal-SCCNFP_vision_codex
=1000mg/kg/dayNOAELdermal-SCCNFP_vision_codex
=1000mg/kg bw/dayNOAEL--SCCS_vision_codex
=1000mg/kg bw/dNOAELoralratSCCS_vision_codex
=1000mg/kg/dayNOAELdermal-SCCNFP_vision_codex
=0.0008mg/kg bwdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50%dermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=500mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=1000mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg/daydevelopmental toxicity-humanUnifiedCodex:SCCNFP:beta.noael_studies
1000mg/kg/daydevelopmental toxicityoralratUnifiedCodex:SCCNFP:beta.noael_studies
1000mg/kg/daydevelopmental toxicityoralratUnifiedCodex:SCCNFP:beta.noael_studies
1000mg/kg bw/daydevelopmental toxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/daydevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/daydevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/daygenotoxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg/dayrepeated dose toxicitydermal-UnifiedCodex:SCCNFP:beta.noael_studies

Showing 41 of 41 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered1,4-bis(2,3-dihydroxypropylamino)anthraquinone421-470-7ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1969767
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for HC Blue 14?

HC Blue 14 (CAS 99788-75-7) is classified under EU CLP Annex VI as Aquatic Chronic 2. Hazard statements: H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for HC Blue 14?

HC Blue 14 has 41 NOAEL studies in the database. The lowest reported value is UVQ553995F UNII. Source: openFDA substances.

What regulatory lists include HC Blue 14?

HC Blue 14 appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is HC Blue 14 used in cosmetics?

Yes, HC Blue 14 is also indexed as a cosmetic ingredient under the name HC Blue No. 14. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for HC Blue 14 come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does HC Blue 14 have different safety status in cosmetics vs industrial chemicals?

HC Blue 14 is prohibited in EU cosmetics but has active industrial GHS classifications (H411).

Is HC Blue 14 used outside industrial chemicals?

HC Blue 14 also appears in cosmetics, pharmaceutical databases.