Is HC Blue No. 14 safe in cosmetics?
HC Blue No. 14 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
HC Blue No. 14
INCI: HC BLUE NO. 14
HC Blue No. 14 (CAS 99788-75-7) is a cosmetic cosmetic ingredient functioning as Hair dyeing (anthraquinone-class direct dye). Reported NOAEL =1000 mg/kg/day (SCCNFP_vision_codex); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 99788-75-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HC Blue No. 14 is prohibited in EU cosmetics but has active industrial GHS classifications (H411).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing (anthraquinone-class direct dye)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1,4-bis(2,3-dihydroxypropylamino)anthracene-9,10-dione
InChIKey
AQNZDXHBYRTSHA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted under coal tar hair dye exemption (21 CFR 740.17)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Blue No. 14.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Blue No. 14. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =0.0008 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0008 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0008 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0008 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =500 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =500 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Pictograms
Environmental Hazard
Hazard Class and Category
Aquatic Chronic 2
Hazard Statements
- H411 Toxic to aquatic life with long lasting effects
Inserted via ATP: ATP01
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0,3%.
BRIN Brazil/India Cosmetics
India: Restricted · max 0,3%
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (4 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 7.0% | - | - | SCCS/0062 |
| measured | 99.2% | in_vitro | - | SCCS/0062 |
| measured | 0.026% | - | - | SCCS/0062 |
| measured | 0.008% | - | - | SCCS/0062 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "99788-75-7", "ingredient_class": "direct_dye", "chemical_class": "anthraquinone", "molecular_weight_Da": "285.30", "color_result_on_hair": "Blue", "shade_range": "fashion_color", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Blue No. 14.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Blue No. 14 by CAS number or substance name.
Studies
20
Lowest NOAEL
0.0008
Highest NOAEL
1000
Units vary across source rows: mg/kg bw/day, mg/kg bw, mg/kg bw/d
SCCS_vision_codex
SCCNFP_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 7.0% | - | - |
| 99.2% | in_vitro | - |
| 0.026% | - | - |
| 0.008% | - | - |
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1969767
Frequently Asked Questions
Is HC Blue No. 14 allowed in the EU?
HC Blue No. 14 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Blue No. 14 do in cosmetics?
HC Blue No. 14 functions as: Hair dyeing (anthraquinone-class direct dye). It is classified as a cosmetic ingredient in our database. CAS number: 99788-75-7.
What is the NOAEL for HC Blue No. 14?
The NOAEL (No Observed Adverse Effect Level) for HC Blue No. 14 is =1000 mg/kg/day based on a repeated dose toxicity study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Is HC Blue No. 14 used outside cosmetics?
HC Blue No. 14 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HC Blue No. 14 have different safety status in cosmetics vs industrial chemicals?
HC Blue No. 14 is prohibited in EU cosmetics but has active industrial GHS classifications (H411).
Compliance Tools
Check HC Blue No. 14 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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