Food Safety Substance

Urea

Urea is a food additive with no EU additive status row found in the EU, FDA has no questions in the US, and data from 8 regulatory sources.

CAS 57-13-6 Indexable evidence set

FDA

FDA has no questions

ADI / TDI

EFSA ADI = 0.002 mg/kg bw/day

Codex

0 row(s)

SOURCE D1 identity resolution e number aliases | Food Additives | dsstox identifiers | 8 matched regulatory source group(s)

Substance Identity

Resolved identifiers used to render this food-safety record.

Substance name

Urea

CAS

57-13-6

DTXSID

DTXSID4021426

PubChem CID

1176

Evidence tier

Indexable evidence set (12)

SOURCE EU Commission FDA | Health Canada | Codex Alimentarius

Multi-Jurisdiction Comparison

Side-by-side status rows for the same resolved substance across public food regulators.

Jurisdiction	Authority	Status	Evidence
United States	FDA	FDA has no questions	GRAS notice
Canada	Health Canada	Listed	Food enzyme

SOURCE FDA FDA GRAS

FDA GRAS Status

US FDA GRAS notice evidence from enriched and notice tables.

Jurisdiction	GRN	Substance	FDA response	Intended use	Basis	Notifier
United States	175	Saccharomyces cerevisiae strain ECMo01 with enhanced expression of urea amidolyase	FDA has no questions	Reduction of ethyl carbamate in fermented beverages	Scientific procedures	First Venture Technologies Corp.
United States	175	<i>Saccharomyces cerevisiae</i> strain ECMo01 with enhanced expression of urea amidolyase	FDA has no questions	Reduction of ethyl carbamate in fermented beverages	Scientific procedures	First Venture Technologies Corp.

SOURCE Health Canada

Health Canada Status

Health Canada food-additive permissions by functional class and food scope.

Jurisdiction	Class	Permitted foods	Maximum level	List
Canada	Food enzyme	Fruit wine; Sake; Wine	Good Manufacturing Practice	List of Permitted Food Enzymes

SOURCE EU Commission EU Food Contact Materials

EU FCM Substances

EU food-contact material rows and migration-limit fields.

Jurisdiction	FCM no.	Ref no.	Substance	Use	SML	Regulation
European Union	107	25960	urea	monomer/macromolecule	-	Regulation (EU) No 10/2011, Annex I
European Union	200	51680	N,N′-diphenylthiourea	additive/PPA	3 mg/kg	Regulation (EU) No 10/2011, Annex I

SOURCE JECFA JECFA ADI

JECFA ADI Values

JECFA ADI records and evaluation years.

Jurisdiction	Chemical name	JECFA no.	CAS	ADI	ADI upper	Function	Evaluation year
JECFA	UREA	-	57-13-6	NOT SPECIFIED	-	TEXTURIZER, THICKENER, YEAST_FOOD, CHEWING_GUM_BASE_COMPOUND	1993

SOURCE ingredients ghs classifications

Cross-Reference to Cosmetics / Chemicals / Pharma

Same-CAS public rows from adjacent Roots verticals where available.

SOURCE Cross-vertical comparison ingredients | ghs classifications

Cross-Vertical Regulatory Divergence

This substance has different regulatory treatment across food, cosmetics, and industrial use.

CosmeticsUreaEU status: permitted Industrial / GHSGHS row foundEuropean Chemicals Agency (ECHA)

SOURCE FAQPage JSON-LD public food renderer rows

Frequently Asked Questions

Food-use, safety, ADI, and cross-vertical answers mirrored into FAQPage JSON-LD.

What is Urea used for in food?

Urea appears in food-use rows as: FORMULATION AID; Food enzyme.

Is Urea safe?

This page does not assign a standalone safety verdict; it renders public regulatory evidence. ADI/reference value: EFSA ADI = 0.002 mg/kg bw/day. US/FDA evidence: FDA has no questions.

What is the ADI for Urea?

Urea has this ADI/reference value in the food-safety tables: EFSA ADI = 0.002 mg/kg bw/day. Source: EFSA 2019.

Is Urea also used in cosmetics?

Urea has a same-CAS cosmetics cross-reference: Urea, EU status permitted.