NOAEL Studies Cosmetic Ingredient

1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate NOAEL Studies

INCI: 1-HYDROXYETHYL 4,5-DIAMINO PYRAZOLE SULFATE

CAS: 155601-30-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =250 mg/ kg body weight/d rat oral 9 wk developmental toxicity 250; 19; 1, p.5
CIR Safety Assessment NOAEL =300 mg/kg body weight/d rat oral - developmental toxicity 300; 900; 20, p.6
CIR Safety Assessment NOAEL =900 mg/kg body weight/d rat oral - developmental toxicity 300; 900; 20, p.6
CIR Safety Assessment NOAEL =1000 mg/kg body weight/day rat - - developmental toxicity 300; 21; 1, p.6
CIR Safety Assessment NOAEL =250 - Sprague Dawley rats oral gavage 13 weeks NOAEL study p.5
CIR Safety Assessment NOAEL =300 - Sprague-Dawley rats oral gavage 9 weeks (males premating), 2 weeks (females premating), through mating, gestation, and lactation (females to postnatal day 21) NOAEL study p.6
CIR Safety Assessment NOAEL =900 - Sprague-Dawley rats oral gavage (maternal dosing) 9 weeks (males premating), 2 weeks (females premating), through mating, gestation, and lactation (females to postnatal day 21) NOAEL study p.6
CIR Safety Assessment NOAEL =1000 - Sprague-Dawley rats oral gavage Gestation days 6-17 NOAEL study p.6
COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 800 mg/kg bw/day rat oral 91 day Subchronic SCCP; Brightwell, J.; DA 010894 13 week oral toxicity study in rats; RTC; 1999
COSMOS DB NOAEL 250 mg/kg bw/day rat oral 91 day Subchronic SCCP; Brightwell, J.; DA 010894 13 week oral toxicity study in rats; RTC; 1999
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_3067; row=3668; data_type=In Vivo; mixture=Chemical; chemical_name=4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate; preferred_name=4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate; dtxsid=DTXSID20165928; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20165928; source_file=acute_oral.xlsx
SCCS Opinion 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.02 mg/kg bw/d rat oral 13-week dermal absorption p.27
SCCS Opinion NOAEL =250 mg/kg bw/day - - 13-week genotoxicity p.14
SCCS Opinion NOAEL =250 mg/kg bw/day - - 13-week NOAEL study p.17
SCCS Opinion NOAEL =250 mg/kg bw/d rat oral 13-week dermal absorption p.27
SCCS Opinion NOAEL =300 mg/kg bw - - - developmental toxicity p.19
SCCS Opinion NOAEL =300 mg/kg rat oral 13-week reproductive toxicity p.23
SCCS Opinion NOAEL =300 mg/kg bw rat oral - developmental toxicity p.24
SCCS Opinion NOAEL =300 mg/kg bw/ day rat oral 13-week reproductive toxicity p.27
SCCS Opinion NOAEL =900 mg/kg bw - - prenatal reproductive toxicity p.18
SCCS Opinion NOAEL =900 mg/kg/day rat - - NOAEL study p.19
SCCS Opinion NOAEL =900 mg/kg bw rat - prenatal reproductive toxicity p.23
SCCS Opinion NOAEL =1000 mg/kg bw/day - - prenatal developmental toxicity p.19
SCCS Opinion NOAEL =1000 mg/kg bw/day rat - - developmental toxicity p.24
Regulatory source 26 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 250 - Sprague Dawley rats oral gavage 13 weeks - p.5
Regulatory source - 300 - Sprague-Dawley rats oral gavage 9 weeks (males premating), 2 weeks (females premating), through mating, gestation, and lactation (females to postnatal day 21) - p.6
Regulatory source - 900 - Sprague-Dawley rats oral gavage (maternal dosing) 9 weeks (males premating), 2 weeks (females premating), through mating, gestation, and lactation (females to postnatal day 21) - p.6
Regulatory source - 1000 - Sprague-Dawley rats oral gavage Gestation days 6-17 - p.6
Regulatory source - 300 - Sprague-Dawley rats oral gavage (maternal dosing) Gestation days 6-17 - p.6
Regulatory source developmental toxicity 250 mg/ kg body weight/d rat oral 9 wk developmental toxicity p.5
Regulatory source developmental toxicity 300 mg/kg body weight/d rat oral - developmental toxicity p.6
Regulatory source developmental toxicity 900 mg/kg body weight/d rat oral - developmental toxicity p.6
Regulatory source developmental toxicity 1000 mg/kg body weight/day rat - - developmental toxicity p.6
Regulatory source - 250 mg/kg bw/day - - 13-week - p.17
Regulatory source - 900 mg/kg/day rat - - - p.19
Regulatory source dermal absorption =0.02 mg/kg bw/d rat oral 13-week dermal absorption p.27
Regulatory source dermal absorption =250 mg/kg bw/d rat oral 13-week dermal absorption p.27
Regulatory source developmental toxicity 300 mg/kg bw - - - developmental toxicity p.19
Regulatory source developmental toxicity 300 mg/kg bw rat oral - developmental toxicity p.24
Regulatory source developmental toxicity 1000 mg/kg bw/day - - prenatal developmental toxicity p.19
Regulatory source developmental toxicity 1000 mg/kg bw/day rat - - developmental toxicity p.24
Regulatory source genotoxicity 250 mg/kg bw/day - - 13-week genotoxicity p.14
Regulatory source reproductive toxicity 250 mg/kg bw/day rat oral 13-week reproductive toxicity p.23
Regulatory source reproductive toxicity 300 mg/kg rat oral 13-week reproductive toxicity p.23
Regulatory source reproductive toxicity 300 mg/kg bw rat oral 13-week reproductive toxicity p.23
Regulatory source reproductive toxicity 300 mg/kg bw/ day rat oral 13-week reproductive toxicity p.27
Regulatory source reproductive toxicity 900 mg/kg bw - - prenatal reproductive toxicity p.18
Regulatory source reproductive toxicity 900 mg/kg bw rat - prenatal reproductive toxicity p.23
Regulatory source reproductive toxicity 900 mg/kg bw/day rat - prenatal reproductive toxicity p.23
Regulatory source reproductive toxicity 1000 mg/kg bw/day rat oral 13-week reproductive toxicity p.23
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 04N8KX12N6 UNII - - - chemical -