NOAEL Studies Cosmetic Ingredient

1,4-Butanediol Dimethacrylate NOAEL Studies

INCI: 1,4-BUTANEDIOL DIMETHACRYLATE

CAS: 2082-81-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =10 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_4585; row=7858; data_type=In Vivo; mixture=Chemical; chemical_name=Butane-1,4-diyl bis(2-methylprop-2-enoate); preferred_name=Butane-1,4-diyl bis(2-methylprop-2-enoate); dtxsid=DTXSID4044870; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4044870; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce04; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13815/7/9/3?documentUUID=5f11e66e-630d-4d79-b839-706ec192f83e; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: clinical biochemistry|maternal: food consumption and compound intake|maternal: histopathology: non-neoplastic|maternal: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15824587:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cb98b8b5a4f5ddfed622bc6d0d6c01e2
ToxValDB_ECHA_IUCLID NOEL =50 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaac3e4b0a7c65d1b7630; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13815/7/9/2?documentUUID=5f11e66e-630d-4d79-b839-706ec192f83e; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=P0: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15856794:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_34e19328a8227c1846d90d5b896b96e5
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =14.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630356:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_119a711e03531c66f0b6c6f89b468a6a
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier KX6732HE0U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H18O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KX6732HE0U"}
openFDA substances FDA UNII substance identifier KX6732HE0U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H18O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KX6732HE0U"}
openFDA substances FDA UNII substance identifier KX6732HE0U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H18O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KX6732HE0U"}
openFDA substances FDA UNII substance identifier KX6732HE0U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H18O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KX6732HE0U"}