Is 1,4-Butanediol Dimethacrylate safe in cosmetics?
1,4-Butanediol Dimethacrylate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
1,4-Butanediol Dimethacrylate
Also known as: 2-Propenoic acid, 2-methyl-, 1,4-butanediyl ester, Butanediol dimethacrylate, Butylene dimethacrylate, 1,4-Butylene dimethacrylate, 1,4-Butylene glycol dimethacrylate (+6 more)
INCI: 1,4-BUTANEDIOL DIMETHACRYLATE
1,4-Butanediol Dimethacrylate (CAS 2082-81-7) is a cosmetic cosmetic ingredient functioning as Film forming agent used primarily in nail products and dental composites. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2082-81-7 →
Auto-generated CPSR Part A draft with source citations
Function
Film forming agent used primarily in nail products and dental composites
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; used in nail enhancements and dental materials
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 1,4-Butanediol Dimethacrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 1,4-Butanediol Dimethacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 1,4-Butanediol Dimethacrylate across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Sens. 1B
Hazard Statements
- H317 May cause an allergic skin reaction
Inserted via ATP: ATP21
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Monomers
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for 1,4-Butanediol Dimethacrylate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 1,4-Butanediol Dimethacrylate by CAS number or substance name.
Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Propenoic acid, 2-methyl-, 1,4-butanediyl ester
Butanediol dimethacrylate
Butylene dimethacrylate
1,4-Butylene dimethacrylate
1,4-Butylene glycol dimethacrylate
EINECS 218-218-1
Methacrylic acid, tetramethylene ester
Oligotetramethylene glycol dimethacrylate
Tetramethylene glycol dimethacrylate
Tetramethylene methacrylate
UNII-KX6732HE0U
Chemical Function
Film former
Monomers
Regulatory Lists
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184875
Frequently Asked Questions
Is 1,4-Butanediol Dimethacrylate allowed in the EU?
1,4-Butanediol Dimethacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,4-Butanediol Dimethacrylate do in cosmetics?
1,4-Butanediol Dimethacrylate functions as: Film forming agent used primarily in nail products and dental composites. It is classified as a cosmetic ingredient in our database. CAS number: 2082-81-7.
What is the NOAEL for 1,4-Butanediol Dimethacrylate?
The NOAEL (No Observed Adverse Effect Level) for 1,4-Butanediol Dimethacrylate is =300 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is 1,4-Butanediol Dimethacrylate used outside cosmetics?
1,4-Butanediol Dimethacrylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 1,4-Butanediol Dimethacrylate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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