1,4-Butanediol Dimethacrylate
INCI: 1,4-BUTANEDIOL DIMETHACRYLATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 1,4-Butanediol Dimethacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=124.1 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
| LOEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 225 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 525 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 225 mg/kg bw/day | oral | rat | oral | REACH |
| LOEL | 262 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | >=124.1 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
GHS Reproductive Toxicity Category 2 (suspected reproductive toxicant). Skin irritant (Category 2). Eye irritant (Category 2). Aquatic toxicity (Acute Category 2). Must be used in polymerized/cured form as residual free monomer presents significant concern.
Frequently Asked Questions
Is 1,4-Butanediol Dimethacrylate safe in cosmetics?
GHS Reproductive Toxicity Category 2 (suspected reproductive toxicant). Skin irritant (Category 2). Eye irritant (Category 2). Aquatic toxicity (Acute Category 2). Must be used in polymerized/cured form as residual free monomer presents significant concern. The EU classifies 1,4-Butanediol Dimethacrylate as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is 1,4-Butanediol Dimethacrylate allowed in the EU?
1,4-Butanediol Dimethacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,4-Butanediol Dimethacrylate do in cosmetics?
1,4-Butanediol Dimethacrylate functions as: Film forming agent used primarily in nail products and dental composites. It is classified as a cosmetic ingredient in our database. CAS number: 2082-81-7.
What is the Margin of Safety for 1,4-Butanediol Dimethacrylate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 1,4-Butanediol Dimethacrylate?
The NOAEL (No Observed Adverse Effect Level) for 1,4-Butanediol Dimethacrylate is 300 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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