Is 1,4-Cyclohexanedicarboxylic Acid safe in cosmetics?
1,4-Cyclohexanedicarboxylic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
1,4-Cyclohexanedicarboxylic Acid
Also known as: 1,4-Dicarboxycyclohexane, EINECS 214-068-6, Hexahydroterephthalic acid, Terephthalic acid, hexahydro-, UNII-13LBH83IU4
INCI: 1,4-CYCLOHEXANEDICARBOXYLIC ACID
1,4-Cyclohexanedicarboxylic Acid (CAS 1076-97-7) is a cosmetic cosmetic ingredient functioning as Chelating agent. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
Function
Chelating agent
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
EC Number
214-068-6
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted; no specific FDA or CIR limitation identified
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 1,4-Cyclohexanedicarboxylic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 1,4-Cyclohexanedicarboxylic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 249 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 1,4-Cyclohexanedicarboxylic Acid across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Editorial summary
Preliminary editorial summary for 1,4-Cyclohexanedicarboxylic Acid — not a computed safety verdict. See the sourced toxicological data above.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 1,4-Cyclohexanedicarboxylic Acid by CAS number or substance name.
Studies
1
Lowest NOAEL
249 mg/kg bw/day
Highest NOAEL
249 mg/kg bw/day
COSMOS DB
Known Synonyms
1,4-Dicarboxycyclohexane
EINECS 214-068-6
Hexahydroterephthalic acid
Terephthalic acid, hexahydro-
UNII-13LBH83IU4
Chemical Function
No specific technical function
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 1,4-Cyclohexanedicarboxylic Acid allowed in the EU?
1,4-Cyclohexanedicarboxylic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,4-Cyclohexanedicarboxylic Acid do in cosmetics?
1,4-Cyclohexanedicarboxylic Acid functions as: Chelating agent. It is classified as a cosmetic ingredient in our database. CAS number: 1076-97-7.
What is the NOAEL for 1,4-Cyclohexanedicarboxylic Acid?
The NOAEL (No Observed Adverse Effect Level) for 1,4-Cyclohexanedicarboxylic Acid is 249 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. Source: COSMOS DB.
Is 1,4-Cyclohexanedicarboxylic Acid used outside cosmetics?
1,4-Cyclohexanedicarboxylic Acid also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 1,4-Cyclohexanedicarboxylic Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acrylates/Vinyl Neodecanoate Crosspolymer
EXCELLENT
Same category
Emulsion stabilising, film forming
Adipic Acid
EXCELLENT
Same category
Buffering
Aluminum Magnesium Oxide
EXCELLENT
Same category
Absorbent, bulking agent, opacifying ...
Ammonium VA/Acrylates Copolymer
EXCELLENT
Same category
Antistatic, binding, film forming, ha...
Ammonium VA/Crotonic Acid Copolymer
EXCELLENT
Same category
Antistatic, film forming, hair fixing...
Aphanothece Sacrum Polysaccharide
EXCELLENT
Same category
Absorbent, emulsion stabilising, film...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
GOOD
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
GOOD
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
GOOD
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
GOOD
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
GOOD
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
GOOD
Similar safety
Antioxidant
2-Isopropyl-5-Methylanisole
GOOD
Chemical family
Flavouring and nutrient; Fragrance
5-Isopropyl-2-Methylanisole
GOOD
Chemical family
Perfuming
1,4-Butanediol
POOR
Browse nearby
Solvent, humectant, viscosity control...
Is 1,4-Cyclohexanedicarboxylic Acid in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 1,4-Cyclohexanedicarboxylic Acid in your formulation.