Is 1,4-Cyclohexanedicarboxylic Acid safe in cosmetics?
1,4-Cyclohexanedicarboxylic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
1,4-Cyclohexanedicarboxylic Acid
Also known as: 1,4-Dicarboxycyclohexane, EINECS 214-068-6, Hexahydroterephthalic acid, Terephthalic acid, hexahydro-, UNII-13LBH83IU4
INCI: 1,4-CYCLOHEXANEDICARBOXYLIC ACID
1,4-Cyclohexanedicarboxylic Acid (CAS 1076-97-7) is a cosmetic cosmetic ingredient functioning as Chelating agent. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1076-97-7 →
Auto-generated CPSR Part A draft with source citations
Function
Chelating agent
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
214-068-6
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted; no specific FDA or CIR limitation identified
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 1,4-Cyclohexanedicarboxylic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 1,4-Cyclohexanedicarboxylic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 249 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 1,4-Cyclohexanedicarboxylic Acid across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for 1,4-Cyclohexanedicarboxylic Acid.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 1,4-Cyclohexanedicarboxylic Acid by CAS number or substance name.
Studies
1
Lowest NOAEL
249 mg/kg bw/day
Highest NOAEL
249 mg/kg bw/day
COSMOS_DB
Known Synonyms
1,4-Dicarboxycyclohexane
EINECS 214-068-6
Hexahydroterephthalic acid
Terephthalic acid, hexahydro-
UNII-13LBH83IU4
Chemical Function
No specific technical function
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 1,4-Cyclohexanedicarboxylic Acid allowed in the EU?
1,4-Cyclohexanedicarboxylic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,4-Cyclohexanedicarboxylic Acid do in cosmetics?
1,4-Cyclohexanedicarboxylic Acid functions as: Chelating agent. It is classified as a cosmetic ingredient in our database. CAS number: 1076-97-7.
What is the NOAEL for 1,4-Cyclohexanedicarboxylic Acid?
The NOAEL (No Observed Adverse Effect Level) for 1,4-Cyclohexanedicarboxylic Acid is 249 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. Source: COSMOS_DB.
Is 1,4-Cyclohexanedicarboxylic Acid used outside cosmetics?
1,4-Cyclohexanedicarboxylic Acid also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 1,4-Cyclohexanedicarboxylic Acid compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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