Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Adipic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 440 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 8000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 8000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 3400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 263 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 288 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 205 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
FDA GRAS with adequate margin of safety; CIR Expert Panel concluded safe at current use levels despite potential for ocular and skin irritation at high concentrations.
Regulatory Flags
Frequently Asked Questions
Is Adipic Acid safe in cosmetics?
FDA GRAS with adequate margin of safety; CIR Expert Panel concluded safe at current use levels despite potential for ocular and skin irritation at high concentrations. The EU classifies Adipic Acid as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Adipic Acid allowed in the EU?
Adipic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Adipic Acid do in cosmetics?
Adipic Acid functions as: Buffering. It is classified as a cosmetic ingredient in our database. CAS number: 124-04-9.
What is the Margin of Safety for Adipic Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Adipic Acid?
The NOAEL (No Observed Adverse Effect Level) for Adipic Acid is 500 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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