NOAEL Studies Cosmetic Ingredient

1,5-Naphthalenediol NOAEL Studies

INCI: 1,5-NAPHTHALENEDIOL

CAS: 83-56-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 50 mg/kg bw/day rat oral 90 day Subchronic SCCP; van Otterdijk, F.M. (2005). Repeated dose 90-day oral toxicity study with A 018 by daily gavage in the rat followed by a 28-day recovery period, NOTOX B.V. internal study code 409545 Archive code at Henkel KGaA, Düsseldorf, Report No. 0500078
SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.02 mg/kg bw/d rat oral 90-day dermal absorption p.20
SCCS Opinion NOAEL =50 mg/kg/day - - Chronic genotoxicity p.16
SCCS Opinion NOAEL =50 mg/kg bw/day rat oral subchronic repeated dose toxicity p.22
SCCS Opinion NOAEL =50 mg/kg bw/day - - Chronic genotoxicity p.15
SCCS Opinion NOAEL =50 mg/kg bw/d rat oral 90-day dermal absorption p.20
SCCS Opinion NOAEL =360 mg/kg bw/day rat - - developmental toxicity p.21
SCCS Opinion NOAEL =360 mg/kg bw/day human - - NOAEL study p.20
ECHA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =50 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf16e4b0a7c65d1cc81b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6013/7/6/2?documentUUID=cb43b050-e37c-4e0b-acbb-a68c876930ad; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15834078:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca837d651097e9672e2d6502242cac2a
Regulatory source 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 360 mg/kg bw/day human - - - p.20
Regulatory source dermal absorption =0.02 mg/kg bw/d rat oral 90-day dermal absorption p.20
Regulatory source dermal absorption =50 mg/kg bw/d rat oral 90-day dermal absorption p.20
Regulatory source developmental toxicity 360 mg/kg bw/day rat - - developmental toxicity p.21
Regulatory source genotoxicity 50 mg/kg/day - - Chronic genotoxicity p.16
Regulatory source genotoxicity 50 mg/kg bw/day - - Chronic genotoxicity p.15
Regulatory source repeated dose toxicity 50 mg/kg bw/day rat oral subchronic repeated dose toxicity p.22
Regulatory source repeated dose toxicity 360 mg/kg bw/day rat oral subchronic repeated dose toxicity p.22
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier P25HC23VH6 UNII - - - chemical -