1,5-Naphthalenediol
INCI: 1,5-NAPHTHALENEDIOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 1,5-Naphthalenediol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 50 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Clastogenic in vitro (chromosomal aberrations in V79 cells, OECD 473) with negative in vivo micronucleus test. Eye irritant causing conjunctival redness and chemosis in rabbits. Kidney pigmentation observed at ≥100 mg/kg oral in rats. Log P = 1.70.
Regulatory Flags
Frequently Asked Questions
Is 1,5-Naphthalenediol safe in cosmetics?
Clastogenic in vitro (chromosomal aberrations in V79 cells, OECD 473) with negative in vivo micronucleus test. Eye irritant causing conjunctival redness and chemosis in rabbits. Kidney pigmentation observed at ≥100 mg/kg oral in rats. Log P = 1.70. The EU classifies 1,5-Naphthalenediol as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is 1,5-Naphthalenediol allowed in the EU?
1,5-Naphthalenediol EU regulatory status: prohibited. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,5-Naphthalenediol do in cosmetics?
1,5-Naphthalenediol functions as: Hair dye precursor/coupler — reacts with primary intermediates under oxidative conditions to form final dye. It is classified as a cosmetic ingredient in our database. CAS number: 83-56-7.
What is the Margin of Safety for 1,5-Naphthalenediol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 1,5-Naphthalenediol?
The NOAEL (No Observed Adverse Effect Level) for 1,5-Naphthalenediol is 50 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Compliance Tools
Check 1,5-Naphthalenediol compliance across multiple jurisdictions:
Related Ingredients
Is 1,5-Naphthalenediol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 1,5-Naphthalenediol in your formulation.