NOAEL Studies
Cosmetic Ingredient
1,6-Hexanediamine NOAEL Studies
INCI: HEXAMETHYLENEDIAMINE
CAS: 124-09-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =792 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1903; row=8856; data_type=In Vivo; mixture=Chemical; chemical_name=1,6-Hexanediamine; preferred_name=1,6-Hexanediamine; dtxsid=DTXSID5024922; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024922; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5024922; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1127 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1904; row=8857; data_type=In Vivo; mixture=Chemical; chemical_name=1,6-Hexanediamine; preferred_name=1,6-Hexanediamine; dtxsid=DTXSID5024922; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024922; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5024922; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =750 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_1902; row=8858; data_type=In Vivo; mixture=Chemical; chemical_name=1,6-Hexanediamine; preferred_name=1,6-Hexanediamine; dtxsid=DTXSID5024922; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024922; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5024922; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=874; RecordID=ARPathway2016_730; DatasetName=ARPathway2016; DTXSID=DTXSID5024922; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024922; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024922 |
NTP_ICE_skin_irritation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | TER | 0.7 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=3613; Record_ID=skin_irritation_invitro_2462; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024922; Assay=TER Corrosion; Endpoint=TER; Response=0.7; Response_Unit=kiloohms; Reference=Botham et al. 1992; 20732113; 10.1016/0887-2333(92)90031-l; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024922; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024922 |
| NTP_ICE_skin_irritation | TER | 0.6 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=3614; Record_ID=skin_irritation_invitro_2464; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024922; Assay=TER Corrosion; Endpoint=TER; Response=0.6; Response_Unit=kiloohms; Reference=Botham et al. 1992; 20732113; 10.1016/0887-2333(92)90031-l; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024922; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024922 |
| NTP_ICE_skin_irritation | TER | 1.1 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=3615; Record_ID=skin_irritation_invitro_2463; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024922; Assay=TER Corrosion; Endpoint=TER; Response=1.1; Response_Unit=kiloohms; Reference=Botham et al. 1992; 20732113; 10.1016/0887-2333(92)90031-l; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024922; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024922 |
ToxValDB_ECHA_IUCLID 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | >2000 | mg/kg bw/day | Rabbit | dermal | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c615eae4b096bca8758d4b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16081/7/3/4?documentUUID=1391a4c2-fe0a-4f97-9ad2-1a1b1e65e2f1; YEAR=1968; ORIGINAL_YEAR=1968; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Dermal_15795361_15795362:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5438e0465ea171b17184656ce6ff4226 |
| ToxValDB_ECHA_IUCLID | LEL | <3160 | mg/kg bw/day | Rabbit | dermal | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c615eae4b096bca8758d4b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16081/7/3/4?documentUUID=1391a4c2-fe0a-4f97-9ad2-1a1b1e65e2f1; YEAR=1968; ORIGINAL_YEAR=1968; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Dermal_15795361_15795362:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7c04affb4bd4111aa43f792ff37676d5 |
| ToxValDB_ECHA_IUCLID | NOAEL | =50 | mg/kg bw/day | Rabbit | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbede; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16081/7/9/3?documentUUID=1391a4c2-fe0a-4f97-9ad2-1a1b1e65e2f1; YEAR=1968; ORIGINAL_YEAR=1968; STUDY_GROUP=ECHA IUCLID:15823736:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_da65fbc6e5e72992bbb287e3f2da2ef8 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~225 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbed6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16081/7/9/3?documentUUID=1391a4c2-fe0a-4f97-9ad2-1a1b1e65e2f1; YEAR=1968; ORIGINAL_YEAR=1968; STUDY_GROUP=ECHA IUCLID:15824155:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_343163329c2e7773394b5e3144303bd9 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~184 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbedc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16081/7/9/3?documentUUID=1391a4c2-fe0a-4f97-9ad2-1a1b1e65e2f1; YEAR=1968; ORIGINAL_YEAR=1968; STUDY_GROUP=ECHA IUCLID:15824156:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b8584b26e8ae52859dc9df7c6111dcb3 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~300 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbedc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16081/7/9/3?documentUUID=1391a4c2-fe0a-4f97-9ad2-1a1b1e65e2f1; YEAR=1968; ORIGINAL_YEAR=1968; STUDY_GROUP=ECHA IUCLID:15824157:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_810ef7f077a1e127548bd93d81021945 |
| ToxValDB_ECHA_IUCLID | NOAEL | =500 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b61f0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16081/7/9/2?documentUUID=1391a4c2-fe0a-4f97-9ad2-1a1b1e65e2f1; YEAR=1968; ORIGINAL_YEAR=1968; STUDY_GROUP=ECHA IUCLID:15862110:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_900ed0f043be029a3b67f9cea618dc98 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =0.54 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632505:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7a39517700cb9aff61b7ed60bc08ad2f |
ToxValDB_HPVIS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | LOAEL | =184 | mg/kg bw/day | Rat | oral | short-term; 7 days | developmental | LONG_REF=Johannsen, F. R. and G. J. Levinskas (1987). J. Appl. Toxicol., 7(4):259-263.Monsanto Co. (1979). IITRI Project No. L8041, Report L8042, Life Sciences Research Institute. "A Teratology Study in Rats" (August).; EXTERNAL_SOURCE_ID=58618; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15642512:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_49ce929c7989aeb62971c79e85ea9c58 |
| ToxValDB_HPVIS | NOAEL | =12.8 | mg/m3 | Rat | Inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Johannsen, F. R. et al. (1987). Fund. Appl. Toxicol., 9:504-511.Monsanto Co. (1979). Report No. BD 79-346 (also cited in TSCA Fiche OTS0001068).; EXTERNAL_SOURCE_ID=63070; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15639366:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a986d9699d5e43750da3cf922bc165e |
| ToxValDB_HPVIS | NOAEL | =112 | mg/kg bw/day | Rat | oral | short-term; 7 days | reproduction developmental | LONG_REF=Johannsen, F. R. and G. J. Levinskas (1987). J. Appl. Toxicol., 7(4):259-263.Monsanto Co. (1979). IITRI Project No. L8041, Report L8042, Life Sciences Research Institute. "A Teratology Study in Rats" (August).; EXTERNAL_SOURCE_ID=59020; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642641_15642748:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_341863812dcd40fa0301675b27985324 |
| ToxValDB_HPVIS | NOAEL | =150 | mg/kg bw/day | Rat | oral | chronic; 40 weeks | reproduction developmental | LONG_REF=Short, R. D. (1991). Fundam. Appl. Toxicol., 16(3):490-494 (DART/9831).Monsanto Co. (1985). International Research and Development Corp. Report IR-83-146, "Hexamethylene Diamine, Two Generation Rat Reproduction Study" (September 20).; EXTERNAL_SOURCE_ID=65761; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15643311:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b97f5a3b3e7a522100aadc6dfcccd997 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | ZRA5J5B2QW | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H16N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZRA5J5B2QW"} |
| openFDA substances | FDA UNII substance identifier | ZRA5J5B2QW | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H16N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZRA5J5B2QW"} |
| openFDA substances | FDA UNII substance identifier | ZRA5J5B2QW | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H16N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZRA5J5B2QW"} |
| openFDA substances | FDA UNII substance identifier | ZRA5J5B2QW | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H16N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZRA5J5B2QW"} |