Is 1,6-Hexanediamine safe in cosmetics?
1,6-Hexanediamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited. 2 toxicological study endpoint(s) are available in our database.
1,6-Hexanediamine
Also known as: 1,6-Diaminohexane, 4-04-00-01320, BRN 1098307, EINECS 204-679-6, Hexane, 1,6-diamino- (+7 more)
INCI: HEXAMETHYLENEDIAMINE
1,6-Hexanediamine (CAS 124-09-4) is a cosmetic cosmetic ingredient functioning as Industrial chemical (nylon monomer); not a typical cosmetic active. Reported NOAEL =50 mg/kg bw/day in Rabbit (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 124-09-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
1,6-Hexanediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H314, H318, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Industrial chemical (nylon monomer); not a typical cosmetic active
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Not a recognized cosmetic ingredient; no FDA cosmetic approval
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 1,6-Hexanediamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 1,6-Hexanediamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =500 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantCorrosive
Hazard Class and Category
Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Corr. 1B
Hazard Statements
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
- H335 May cause respiratory irritation
- H314 Causes severe skin burns and eye damage
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Chemical reaction regulator
pH regulating agent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for 1,6-Hexanediamine.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 1,6-Hexanediamine by CAS number or substance name.
Studies
8
Lowest NOAEL
25 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
1,6-Diaminohexane
4-04-00-01320
BRN 1098307
EINECS 204-679-6
Hexane, 1,6-diamino-
NCI-C61405
UNII-ZRA5J5B2QW
1,6-hexamethylenediamine
H2N(CH2)6NH2
HEX-NH2
HMDA
diaminohexane
Chemical Function
pH regulating agent
Binder
Chemical reaction regulator
Regulatory Lists
Cons electronics mech appliances and machinery; Europe
Canada; pharmaceutical
drinking_water; Europe; manufacturing; plastic_additive
CEDI
Indirect additives food contact (10/2018)
drinking_water; Europe; manufacturing; plastic_additive
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL303004
Frequently Asked Questions
Is 1,6-Hexanediamine allowed in the EU?
1,6-Hexanediamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,6-Hexanediamine do in cosmetics?
1,6-Hexanediamine functions as: Industrial chemical (nylon monomer); not a typical cosmetic active. It is classified as a cosmetic ingredient in our database. CAS number: 124-09-4.
What is the NOAEL for 1,6-Hexanediamine?
The NOAEL (No Observed Adverse Effect Level) for 1,6-Hexanediamine is =50 mg/kg bw/day based on a developmental study via oral route in Rabbit. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is 1,6-Hexanediamine used outside cosmetics?
1,6-Hexanediamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 1,6-Hexanediamine have different safety status in cosmetics vs industrial chemicals?
1,6-Hexanediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H314, H318, H335).
Compliance Tools
Check 1,6-Hexanediamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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