NOAEL Studies Cosmetic Ingredient

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE NOAEL Studies

CAS: 1603-02-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 50 mg/kg bw/day rat oral 90 day Subchronic SCCP; H. Schmid, K. Biedermann, H. Luetkemeier, K. Weber, 1995; Subchronic 13-week oral(gavage) toxicity study with 4-OH-2,5,6-triamino-pyrimidine (sulphate) in the rat, RCCProject No. 376255, Test Report, Itingen/CH, October 31, 1995
SCCNFP Opinion 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =200 mg/kg bw rat oral Subchronic repeated dose toxicity p.7
SCCNFP Opinion NOAEL =1000 mg/kg bw rat - - dermal absorption p.11
SCCS Opinion 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.83 mg/kg bw/d rat oral 90-day dermal absorption p.20
SCCS Opinion NOAEL =100 mg/kg bw/d rat oral 90-day dermal absorption p.20
SCCS Opinion NOAEL =200 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.13
SCCS Opinion NOAEL =200 mg/kg bw/d rat oral 90-day dermal absorption p.20
SCCS Opinion NOAEL =1000 mg/kg bw/day human - - NOAEL study p.18
Regulatory source 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source dermal absorption 1000 mg/kg bw rat - - dermal absorption p.11
Regulatory source repeated dose toxicity 200 mg/kg bw rat oral Subchronic repeated dose toxicity p.7
Regulatory source repeated dose toxicity 200 mg/kg bw rabbit dermal Sub-chronic repeated dose toxicity p.8
Regulatory source - 200 mg/kg bw/day - - - - p.13
Regulatory source - 1000 mg/kg bw/day human - - - p.18
Regulatory source - 1000 mg/kg bw/day - - - - p.19
Regulatory source dermal absorption =0.83 mg/kg bw/d rat oral 90-day dermal absorption p.20
Regulatory source dermal absorption =100 mg/kg bw/d rat oral 90-day dermal absorption p.20
Regulatory source dermal absorption =200 mg/kg bw/d rat oral 90-day dermal absorption p.20
Regulatory source genotoxicity 200 mg/kg bw/day - - Chronic genotoxicity p.14
Regulatory source repeated dose toxicity 200 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.13
Regulatory source repeated dose toxicity 200 mg/kg bw/day rat oral subchronic repeated dose toxicity p.19
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier T3YK834X4U UNII - - - chemical -