NOAEL Studies Cosmetic Ingredient

2,5-XYLENOL NOAEL Studies

CAS: 95-87-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_adme_parameters 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 33.8 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2517; Record_ID=adme_parameters_845; Data_Type=Measured; DTXSID=DTXSID6025145; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=33.8; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025145; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025145
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1976; RecordID=ARPathway2016_1771; DatasetName=ARPathway2016; DTXSID=DTXSID6025145; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025145; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025145
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =1000 mM Mouse dermal short-term; 8 days short-term LONG_REF=Toxicology232(1-2): 132-137 Yamano,T., M. Ichihara, M. Shimizu, T. Noda, and Y. Tsujimoto Immunomodulatory Effects of Mono-, di-, and Trimethylphenols in Mice 2007; TITLE=Immunomodulatory Effects of Mono-, di-, and Trimethylphenols in Mice; AUTHOR=Yamano,T., M. Ichihara, M. Shimizu, T. Noda, and Y. Tsujimoto; DOI=10.1016/j.tox.2006.12.021; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=115071; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Cell(s): Lymphocyte|Immunological: Lymphocyte activity; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603201_15606635:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e05e20b5b917076c6ad1c204c025d64e
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =3.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635730:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_611736e6d3ba73c34e8d774991383bca
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier XH3E3564KX UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XH3E3564KX"}
openFDA substances FDA UNII substance identifier XH3E3564KX UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XH3E3564KX"}
openFDA substances FDA UNII substance identifier XH3E3564KX UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XH3E3564KX"}
openFDA substances FDA UNII substance identifier XH3E3564KX UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XH3E3564KX"}