NOAEL Studies
Cosmetic Ingredient
2-Acetonaphthone NOAEL Studies
INCI: 2-ACETONAPHTHONE
CAS: 93-08-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 36.9 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =33 | mg/kg | Rat | oral: feed | 90 days | subchronic | EFSA AFC - 2006 - OutputID 2231 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 16: Aromatic ketones from chemical group 21 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - doi:10.2903/j.efsa.2006.330 |
| EFSA | NOAEL | =33 | mg/kg bw/day | Rat | - | 90 days | subchronic | EFSA AFC - 2008 - OutputID 2287 - Flavouring Group Evaluation 69, (FGE.69): Consideration of aromatic substituted secondary alcohols, ketones and related esters evaluated by JECFA (57th meeting) structurally related to aromatic ketones from chemical group 21 evaluated by EFSA in FGE.16 (2006). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food - doi:10.2903/j.efsa.2008.869 |
| EFSA | NOAEL | =33 | mg/kg | Rat | oral: feed | 90 days | subchronic | EFSA AFC - 2006 - OutputID 2231 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 16: Aromatic ketones from chemical group 21 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - doi:10.2903/j.efsa.2006.330 |
| EFSA | NOAEL | =33 | mg/kg bw/day | Rat | - | 90 days | subchronic | EFSA AFC - 2008 - OutputID 2287 - Flavouring Group Evaluation 69, (FGE.69): Consideration of aromatic substituted secondary alcohols, ketones and related esters evaluated by JECFA (57th meeting) structurally related to aromatic ketones from chemical group 21 evaluated by EFSA in FGE.16 (2006). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food - doi:10.2903/j.efsa.2008.869 |
| EFSA | NOAEL | =33 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA AFC (2006). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 16: Aromatic ketones from chemical group 21 (Commission Regulation (EC) No 1565/2000 of 18 July 2000). doi:10.2903/j.efsa.2006.330.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 16: Aromatic ketones from chemical group 21 (Commission Regulation (EC) No 1565/2000 of 18 July 2000); AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2006.330; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA_dup_-_15620821_15620822_15620823:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5abf1f2077c2fcc2c73f3a7c328bc721 |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 32.598468960281 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2140; RecordID=ERPathway2016_471; DatasetName=ERPathway2016; DTXSID=DTXSID2041389; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=32.598468960281; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389 |
| NTP ICE endocrine | ACC | 50.5714407806539 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2141; RecordID=ERPathway2016_471; DatasetName=ERPathway2016; DTXSID=DTXSID2041389; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=50.5714407806539; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2136; RecordID=ARPathway2016_1725; DatasetName=ARPathway2016; DTXSID=DTXSID2041389; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389 |
| NTP ICE endocrine | Model Score | 0.00257 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=2142; RecordID=ERPathway2016_471; DatasetName=ERPathway2016; DTXSID=DTXSID2041389; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00257; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389 |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11086; Record_ID=skin_sensitization_invivo_2424; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2041389; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90256-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389 |
| NTP ICE skin sensitization | Induction dose per skin area | 1296 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11084; Record_ID=skin_sensitization_invivo_2424; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2041389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90256-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11089; Record_ID=skin_sensitization_invivo_2424; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2041389; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90256-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =1.63 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629473:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f5273b47f4b055410691a5406d1c8c56 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 21D49LOP2T | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"21D49LOP2T"} |
| openFDA substances | FDA UNII substance identifier | 21D49LOP2T | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"21D49LOP2T"} |
| openFDA substances | FDA UNII substance identifier | 21D49LOP2T | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"21D49LOP2T"} |
| openFDA substances | FDA UNII substance identifier | 21D49LOP2T | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"21D49LOP2T"} |