NOAEL Studies Cosmetic Ingredient

2-Amino-3-Hydroxypyridine NOAEL Studies

INCI: 2-AMINO-3-HYDROXYPYRIDINE

CAS: 16867-03-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB LOAEL 60 mg/kg bw/day rat oral 91 day Subchronic SCCP; Hruby, R. (2005) A 132: 90-day oral toxicity study with rats. ARC Seibersdorfresearch GmbH, Seibersdorf, Austria, internal study code: HE 92 Archive code atHenkel KGaA, Düsseldorf, Report No. R 0500256
COSMOS_DB NOAEL 30 mg/kg bw/day rat oral 91 day Subchronic SCCP; Hruby, R. (2005) A 132: 90-day oral toxicity study with rats. ARC Seibersdorfresearch GmbH, Seibersdorf, Austria, internal study code: HE 92 Archive code atHenkel KGaA, Düsseldorf, Report No. R 0500256
SCCS_vision_codex 16 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS_vision_codex NOAEL =30 mg/kg bw/day - - Chronic genotoxicity {"citation":"Ref.: 14 3","dose":"tassium, protein and alanine aminotransferase levels were increased at the high dose male group.","effect":"tassium, protein and alanine aminotransferase levels were increased at the high dose male group. In high dose female group aspartate aminotransferase was increased and cholesterol was decreased. The differences in kidney and liver weights at the end of exposure were noted. However, the histopathological findings gave no indication of the cause of the weight change. In the liver the histopathology changes were necrosis in mid and high dose groups. Conclusions Based on the histopathological changes in the liver the NOAEL was set to 30 mg/kg bw/day. Ref.: 14 3.3.5.3. Chronic (> 12 months) toxicity No data submitted 3.3.6. Mutagenicity / Genotoxicity 3.3.6.1 Mutagenicity / Genotoxicity in vitro Bacterial Reverse Mutation Test Guideline: OECD 471 (1997) Species/strain: TA 1535, TA 1537, TA 98, TA 100 and TA 102 Replicates: Triplicates in two independent experiments Test substance: A 132 Solvent: DMSO Batch: Lot 02-03-01 Purity: > 99.9% (area%, HPLC) Concentrations: 0, 33, 100, 333, 1000, 2500, 5000 µg/plate Treatment: Experimen","page":14,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_001"}
SCCS_vision_codex NOAEL =45 mg/kg bw/day - - - NOAEL study {"citation":"Ref.: 16 3","dose":"occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted.","effect":"occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted. However, there was no dose response on these variations. Statistically significant increase in the incidence of rudiment lumbar ribs and variations were observed in the highest dose group. Conclusions Because of the death of dams and reduced body weight gain at the highest dose group, the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, the NOAEL for embryotoxicity is also determined to be 45 mg/kg bw/day. Ref.: 16 3.3.9. Toxicokinetics No data submitted","page":19,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_002"}
SCCS_vision_codex NOAEL =0.02 mg/kg bw rat oral 90-day dermal absorption {"dose":"Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...","effect":"o data submitted 3.3.11. Human data No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility","page":20,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_004"}
SCCS_vision_codex NOAEL =30 mg/kg bw rat oral 90-day dermal absorption {"dose":"Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...","effect":"ata No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility and Lo","page":20,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_005"}
SCCS_vision_codex NOAEL =30 mg/kg bw/day - - Chronic genotoxicity {"citation":"Ref.: 14 3","dose":"tassium, protein and alanine aminotransferase levels were increased at the high dose male group.","effect":"tassium, protein and alanine aminotransferase levels were increased at the high dose male group. In high dose female group aspartate aminotransferase was increased and cholesterol was decreased. The differences in kidney and liver weights at the end of exposure were noted. However, the histopathological findings gave no indication of the cause of the weight change. In the liver the histopathology changes were necrosis in mid and high dose groups. Conclusions Based on the histopathological changes in the liver the NOAEL was set to 30 mg/kg bw/day. Ref.: 14 3.3.5.3. Chronic (> 12 months) toxicity No data submitted 3.3.6. Mutagenicity / Genotoxicity 3.3.6.1 Mutagenicity / Genotoxicity in vitro Bacterial Reverse Mutation Test Guideline: OECD 471 (1997) Species/strain: TA 1535, TA 1537, TA 98, TA 100 and TA 102 Replicates: Triplicates in two independent experiments Test substance: A 132 Solvent: DMSO Batch: Lot 02-03-01 Purity: > 99.9% (area%, HPLC) Concentrations: 0, 33, 100, 333, 1000, 2500, 5000 µg/plate Treatment: Experimen","page":14,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_001"}
SCCS_vision_codex NOAEL =45 mg/kg bw/day - - - NOAEL study {"citation":"Ref.: 16 3","dose":"occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted.","effect":"occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted. However, there was no dose response on these variations. Statistically significant increase in the incidence of rudiment lumbar ribs and variations were observed in the highest dose group. Conclusions Because of the death of dams and reduced body weight gain at the highest dose group, the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, the NOAEL for embryotoxicity is also determined to be 45 mg/kg bw/day. Ref.: 16 3.3.9. Toxicokinetics No data submitted","page":19,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_002"}
SCCS_vision_codex NOAEL =0.02 mg/kg bw rat oral 90-day dermal absorption {"dose":"Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...","effect":"o data submitted 3.3.11. Human data No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility","page":20,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_004"}
SCCS_vision_codex NOAEL =30 mg/kg bw rat oral 90-day dermal absorption {"dose":"Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...","effect":"ata No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility and Lo","page":20,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_005"}
SCCS_vision_codex NOAEL =30 mg/kg bw/day - - Chronic genotoxicity {"citation":"Ref.: 14 3","dose":"tassium, protein and alanine aminotransferase levels were increased at the high dose male group.","effect":"tassium, protein and alanine aminotransferase levels were increased at the high dose male group. In high dose female group aspartate aminotransferase was increased and cholesterol was decreased. The differences in kidney and liver weights at the end of exposure were noted. However, the histopathological findings gave no indication of the cause of the weight change. In the liver the histopathology changes were necrosis in mid and high dose groups. Conclusions Based on the histopathological changes in the liver the NOAEL was set to 30 mg/kg bw/day. Ref.: 14 3.3.5.3. Chronic (> 12 months) toxicity No data submitted 3.3.6. Mutagenicity / Genotoxicity 3.3.6.1 Mutagenicity / Genotoxicity in vitro Bacterial Reverse Mutation Test Guideline: OECD 471 (1997) Species/strain: TA 1535, TA 1537, TA 98, TA 100 and TA 102 Replicates: Triplicates in two independent experiments Test substance: A 132 Solvent: DMSO Batch: Lot 02-03-01 Purity: > 99.9% (area%, HPLC) Concentrations: 0, 33, 100, 333, 1000, 2500, 5000 µg/plate Treatment: Experimen","page":14,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_001"}
SCCS_vision_codex NOAEL =45 mg/kg bw/day - - - NOAEL study {"citation":"Ref.: 16 3","dose":"occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted.","effect":"occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted. However, there was no dose response on these variations. Statistically significant increase in the incidence of rudiment lumbar ribs and variations were observed in the highest dose group. Conclusions Because of the death of dams and reduced body weight gain at the highest dose group, the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, the NOAEL for embryotoxicity is also determined to be 45 mg/kg bw/day. Ref.: 16 3.3.9. Toxicokinetics No data submitted","page":19,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_002"}
SCCS_vision_codex NOAEL =0.02 mg/kg bw rat oral 90-day dermal absorption {"dose":"Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...","effect":"o data submitted 3.3.11. Human data No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility","page":20,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_004"}
SCCS_vision_codex NOAEL =30 mg/kg bw rat oral 90-day dermal absorption {"dose":"Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...","effect":"ata No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility and Lo","page":20,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_005"}
SCCS_vision_codex NOAEL =30 mg/kg bw/day - - Chronic genotoxicity {"citation":"Ref.: 14 3","dose":"tassium, protein and alanine aminotransferase levels were increased at the high dose male group.","effect":"tassium, protein and alanine aminotransferase levels were increased at the high dose male group. In high dose female group aspartate aminotransferase was increased and cholesterol was decreased. The differences in kidney and liver weights at the end of exposure were noted. However, the histopathological findings gave no indication of the cause of the weight change. In the liver the histopathology changes were necrosis in mid and high dose groups. Conclusions Based on the histopathological changes in the liver the NOAEL was set to 30 mg/kg bw/day. Ref.: 14 3.3.5.3. Chronic (> 12 months) toxicity No data submitted 3.3.6. Mutagenicity / Genotoxicity 3.3.6.1 Mutagenicity / Genotoxicity in vitro Bacterial Reverse Mutation Test Guideline: OECD 471 (1997) Species/strain: TA 1535, TA 1537, TA 98, TA 100 and TA 102 Replicates: Triplicates in two independent experiments Test substance: A 132 Solvent: DMSO Batch: Lot 02-03-01 Purity: > 99.9% (area%, HPLC) Concentrations: 0, 33, 100, 333, 1000, 2500, 5000 µg/plate Treatment: Experimen","page":14,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_001"}
SCCS_vision_codex NOAEL =45 mg/kg bw/day - - - NOAEL study {"citation":"Ref.: 16 3","dose":"occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted.","effect":"occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted. However, there was no dose response on these variations. Statistically significant increase in the incidence of rudiment lumbar ribs and variations were observed in the highest dose group. Conclusions Because of the death of dams and reduced body weight gain at the highest dose group, the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, the NOAEL for embryotoxicity is also determined to be 45 mg/kg bw/day. Ref.: 16 3.3.9. Toxicokinetics No data submitted","page":19,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_002"}
SCCS_vision_codex NOAEL =0.02 mg/kg bw rat oral 90-day dermal absorption {"dose":"Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...","effect":"o data submitted 3.3.11. Human data No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility","page":20,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_004"}
SCCS_vision_codex NOAEL =30 mg/kg bw rat oral 90-day dermal absorption {"dose":"Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...","effect":"ata No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility and Lo","page":20,"pdf":"sccp_o_127.pdf","row_type":"noael_study","study_id":"sccp_o_127_noael_005"}
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =45 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabf4e4b0a7c65d1bca76; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20708/7/9/3?documentUUID=609ca98b-8aa6-46ba-af68-283e5f23fcbf; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: changes in postnatal survival|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821068:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e41dca4d15ed8329ec576759ccb9c1a
ToxValDB_ECHA_IUCLID NOAEL =30 mg/kg bw/day Rat oral chronic; 91 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c536a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20708/7/6/2?documentUUID=609ca98b-8aa6-46ba-af68-283e5f23fcbf; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=behaviour (functional findings)|urinalysis|water consumption and compound intake|body weight and weight gain|clinical biochemistry|food consumption and compound intake|gross pathology|haematology|histopathology: neoplastic|mortality|ophthalmological examination|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|food and/or water consumption|gross pathology|hematology|mortality/survival|neurobehavior|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15846346:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_716b947741141c1a81856c52d5a653f2
UnifiedCodex:SCCS_SHADOW:beta.noael_studies 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
UnifiedCodex:SCCS_SHADOW:beta.noael_studies - 45 mg/kg bw/day - - - - SOURCE_SUBDIR=sccp_o_127; REPORT_TITLE=OPINION ON 2-Amino-3-hydroxypyridine COLIPA n° A132; OPINION_NUMBER=SCCP/1126/07; COMMITTEE=Scientific Committee on Consumer Products (SCCP); REPORT_DATE=15 April 2008; VALUE_TEXT=45; DOSE=occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted.; EFFECT=occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted. However, there was no dose response on these variations. Statistically significant increase in the incidence of rudiment lumbar ribs and variations were observed in the highest dose group. Conclusions Because of the death of dams and reduced body weight gain at the highest dose group, the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, the NOAEL for embryotoxicity is also determined to be 45 mg/kg bw/day. Ref.: 16 3.3.9. Toxicokinetics No data submitted; CITATION=Ref.: 16 3; CITATION_NUMBERS=[16,3]; REFERENCE=Ref.: 16 3; DETAILS_JSON={"cas_number":"16867-03-1","citation":"Ref.: 16 3","dose":"occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted.","duration":"","effect":"occurrence of a statistically significant increase in incompletely ossified caudal vertebrae in the mid dose group and statistically significant increase in incompletely ossified pelvis in the low and mid dose group were noted. However, there was no dose response on these variations. Statistically significant increase in the incidence of rudiment lumbar ribs and variations were observed in the highest dose group. Conclusions Because of the death of dams and reduced body weight gain at the highest dose group, the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, the NOAEL for embryotoxicity is also determined to be 45 mg/kg bw/day. Ref.: 16 3.3.9. Toxicokinetics No data submitted","endpoint":"","ingredient":"in line","loael_value":"","noael_unit":"mg/kg bw/day","noael_value":"45","page":19,"route":"","species":"","study_id":"sccp_o_127_noael_002"}
UnifiedCodex:SCCS_SHADOW:beta.noael_studies - 45 mg/kg bw/day - - - - SOURCE_SUBDIR=sccp_o_127; REPORT_TITLE=OPINION ON 2-Amino-3-hydroxypyridine COLIPA n° A132; OPINION_NUMBER=SCCP/1126/07; COMMITTEE=Scientific Committee on Consumer Products (SCCP); REPORT_DATE=15 April 2008; VALUE_TEXT=45; DOSE=ied pelvis in the low and mid dose group were noted.; EFFECT=ied pelvis in the low and mid dose group were noted. However, there was no dose response on these variations. Statistically significant increase in the incidence of rudiment lumbar ribs and variations were observed in the highest dose group. Conclusions Because of the death of dams and reduced body weight gain at the highest dose group, the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, the NOAEL for embryotoxicity is also determined to be 45 mg/kg bw/day. Ref.: 16 3.3.9. Toxicokinetics No data submitted; CITATION=Ref.: 16 3; CITATION_NUMBERS=[16,3]; REFERENCE=Ref.: 16 3; DETAILS_JSON={"cas_number":"16867-03-1","citation":"Ref.: 16 3","dose":"ied pelvis in the low and mid dose group were noted.","duration":"","effect":"ied pelvis in the low and mid dose group were noted. However, there was no dose response on these variations. Statistically significant increase in the incidence of rudiment lumbar ribs and variations were observed in the highest dose group. Conclusions Because of the death of dams and reduced body weight gain at the highest dose group, the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, the NOAEL for embryotoxicity is also determined to be 45 mg/kg bw/day. Ref.: 16 3.3.9. Toxicokinetics No data submitted","endpoint":"","ingredient":"in line","loael_value":"","noael_unit":"mg/kg bw/day","noael_value":"45","page":19,"route":"","species":"","study_id":"sccp_o_127_noael_003"}
UnifiedCodex:SCCS_SHADOW:beta.noael_studies dermal absorption =0.02 mg/kg bw rat oral 90-day dermal absorption SOURCE_SUBDIR=sccp_o_127; REPORT_TITLE=OPINION ON 2-Amino-3-hydroxypyridine COLIPA n° A132; OPINION_NUMBER=SCCP/1126/07; COMMITTEE=Scientific Committee on Consumer Products (SCCP); REPORT_DATE=15 April 2008; VALUE_TEXT== 0.02; DOSE=Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...; EFFECT=o data submitted 3.3.11. Human data No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"16867-03-1","citation":"","dose":"Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...","duration":"90-day","effect":"o data submitted 3.3.11. Human data No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility","endpoint":"dermal absorption","ingredient":"in line","loael_value":"","noael_unit":"mg/kg bw","noael_value":"= 0.02","page":20,"route":"oral","species":"rat","study_id":"sccp_o_127_noael_004"}
UnifiedCodex:SCCS_SHADOW:beta.noael_studies dermal absorption =30 mg/kg bw rat oral 90-day dermal absorption SOURCE_SUBDIR=sccp_o_127; REPORT_TITLE=OPINION ON 2-Amino-3-hydroxypyridine COLIPA n° A132; OPINION_NUMBER=SCCP/1126/07; COMMITTEE=Scientific Committee on Consumer Products (SCCP); REPORT_DATE=15 April 2008; VALUE_TEXT== 30; DOSE=Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...; EFFECT=ata No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility and Lo; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"16867-03-1","citation":"","dose":"Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...","duration":"90-day","effect":"ata No data submitted 3.3.12. Special investigations No data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility and Lo","endpoint":"dermal absorption","ingredient":"in line","loael_value":"","noael_unit":"mg/kg bw","noael_value":"= 30","page":20,"route":"oral","species":"rat","study_id":"sccp_o_127_noael_005"}
UnifiedCodex:SCCS_SHADOW:beta.noael_studies dermal absorption =30 mg/kg bw rat oral 90-day dermal absorption SOURCE_SUBDIR=sccp_o_127; REPORT_TITLE=OPINION ON 2-Amino-3-hydroxypyridine COLIPA n° A132; OPINION_NUMBER=SCCP/1126/07; COMMITTEE=Scientific Committee on Consumer Products (SCCP); REPORT_DATE=15 April 2008; VALUE_TEXT== 30; DOSE=Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...; EFFECT=data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility and Log Pow of the test material are not adequate. The content o; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"16867-03-1","citation":"","dose":"Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exp...","duration":"90-day","effect":"data submitted 3.3.13. Safety evaluation (including calculation of the MoS) CALCULATION OF THE MARGIN OF SAFETY (2-amino-3-hydroxypyridine) (oxidative - permanent) Maximum absorption through the skin A (µg/cm2) = 1.61 µg/cm² Skin Area surface SAS (cm2) = 700 cm2 Dermal absorption per treatment SAS x A x 0.001 = 1.13 mg Typical body weight of human = 60 kg Systemic exposure dose (SED) SAS x A x 0.001/60 = 0.02 mg/kg bw No observed adverse effect level NOAEL = 30 mg/kg bw (90-day, rat, oral) Margin of Safety NOAEL / SED = 1500 3.3.14. Discussion Physico-chemical properties 2-Amino-3-hydroxypyridine is used as a precursor for hair colours. It reacts with primary intermediates to form the final dye-stuff. The reaction can be accelerated by the addition of an oxidizing agent (e.g. hydrogen peroxide), but can also be achieved by air oxidation. The final concentration of 2-Amino-3-hydroxypyridine on head can be up to 1.0%. The reported values of water solubility and Log Pow of the test material are not adequate. The content o","endpoint":"dermal absorption","ingredient":"in line","loael_value":"","noael_unit":"mg/kg bw","noael_value":"= 30","page":20,"route":"oral","species":"rat","study_id":"sccp_o_127_noael_006"}
UnifiedCodex:SCCS_SHADOW:beta.noael_studies genotoxicity 30 mg/kg bw/day - - Chronic genotoxicity SOURCE_SUBDIR=sccp_o_127; REPORT_TITLE=OPINION ON 2-Amino-3-hydroxypyridine COLIPA n° A132; OPINION_NUMBER=SCCP/1126/07; COMMITTEE=Scientific Committee on Consumer Products (SCCP); REPORT_DATE=15 April 2008; VALUE_TEXT=30; DOSE=tassium, protein and alanine aminotransferase levels were increased at the high dose male group.; EFFECT=tassium, protein and alanine aminotransferase levels were increased at the high dose male group. In high dose female group aspartate aminotransferase was increased and cholesterol was decreased. The differences in kidney and liver weights at the end of exposure were noted. However, the histopathological findings gave no indication of the cause of the weight change. In the liver the histopathology changes were necrosis in mid and high dose groups. Conclusions Based on the histopathological changes in the liver the NOAEL was set to 30 mg/kg bw/day. Ref.: 14 3.3.5.3. Chronic (> 12 months) toxicity No data submitted 3.3.6. Mutagenicity / Genotoxicity 3.3.6.1 Mutagenicity / Genotoxicity in vitro Bacterial Reverse Mutation Test Guideline: OECD 471 (1997) Species/strain: TA 1535, TA 1537, TA 98, TA 100 and TA 102 Replicates: Triplicates in two independent experiments Test substance: A 132 Solvent: DMSO Batch: Lot 02-03-01 Purity: > 99.9% (area%, HPLC) Concentrations: 0, 33, 100, 333, 1000, 2500, 5000 µg/plate Treatment: Experimen; CITATION=Ref.: 14 3; CITATION_NUMBERS=[14,3]; REFERENCE=Ref.: 14 3; DETAILS_JSON={"cas_number":"16867-03-1","citation":"Ref.: 14 3","dose":"tassium, protein and alanine aminotransferase levels were increased at the high dose male group.","duration":"Chronic","effect":"tassium, protein and alanine aminotransferase levels were increased at the high dose male group. In high dose female group aspartate aminotransferase was increased and cholesterol was decreased. The differences in kidney and liver weights at the end of exposure were noted. However, the histopathological findings gave no indication of the cause of the weight change. In the liver the histopathology changes were necrosis in mid and high dose groups. Conclusions Based on the histopathological changes in the liver the NOAEL was set to 30 mg/kg bw/day. Ref.: 14 3.3.5.3. Chronic (> 12 months) toxicity No data submitted 3.3.6. Mutagenicity / Genotoxicity 3.3.6.1 Mutagenicity / Genotoxicity in vitro Bacterial Reverse Mutation Test Guideline: OECD 471 (1997) Species/strain: TA 1535, TA 1537, TA 98, TA 100 and TA 102 Replicates: Triplicates in two independent experiments Test substance: A 132 Solvent: DMSO Batch: Lot 02-03-01 Purity: > 99.9% (area%, HPLC) Concentrations: 0, 33, 100, 333, 1000, 2500, 5000 µg/plate Treatment: Experimen","endpoint":"genotoxicity","ingredient":"in line","loael_value":"","noael_unit":"mg/kg bw/day","noael_value":"30","page":14,"route":"","species":"","study_id":"sccp_o_127_noael_001"}
UnifiedCodex:SCCS_SHADOW:beta.noael_studies irritation 30 mg/kg bw/day rat - 90-day irritation SOURCE_SUBDIR=sccp_o_127; REPORT_TITLE=OPINION ON 2-Amino-3-hydroxypyridine COLIPA n° A132; OPINION_NUMBER=SCCP/1126/07; COMMITTEE=Scientific Committee on Consumer Products (SCCP); REPORT_DATE=15 April 2008; VALUE_TEXT=30; DOSE=SCCP/1126/07 Opinion on 2-amino-3-hydroxypyridine 21 In a 90-day study on rats, the NOAEL was set at 30 mg/kg bw/day, based on the histopathological changes in the liver.; EFFECT=SCCP/1126/07 Opinion on 2-amino-3-hydroxypyridine 21 In a 90-day study on rats, the NOAEL was set at 30 mg/kg bw/day, based on the histopathological changes in the liver. Because of the death of dams at the highest dose group the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, NOAEL for embryotoxicity is determined to be 45 mg/kg bw/day. Irritation / sensitisation Based on the criteria of the test system, 2-Amino-3-hydroxypyridine was not irritant to rabbit skin. Undiluted 2-Ami; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"16867-03-1","citation":"","dose":"SCCP/1126/07 Opinion on 2-amino-3-hydroxypyridine 21 In a 90-day study on rats, the NOAEL was set at 30 mg/kg bw/day, based on the histopathological changes in the liver.","duration":"90-day","effect":"SCCP/1126/07 Opinion on 2-amino-3-hydroxypyridine 21 In a 90-day study on rats, the NOAEL was set at 30 mg/kg bw/day, based on the histopathological changes in the liver. Because of the death of dams at the highest dose group the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, NOAEL for embryotoxicity is determined to be 45 mg/kg bw/day. Irritation / sensitisation Based on the criteria of the test system, 2-Amino-3-hydroxypyridine was not irritant to rabbit skin. Undiluted 2-Ami","endpoint":"irritation","ingredient":"in line","loael_value":"","noael_unit":"mg/kg bw/day","noael_value":"30","page":21,"route":"","species":"rat","study_id":"sccp_o_127_noael_007"}
UnifiedCodex:SCCS_SHADOW:beta.noael_studies irritation 45 mg/kg bw/day rat - 90-day irritation SOURCE_SUBDIR=sccp_o_127; REPORT_TITLE=OPINION ON 2-Amino-3-hydroxypyridine COLIPA n° A132; OPINION_NUMBER=SCCP/1126/07; COMMITTEE=Scientific Committee on Consumer Products (SCCP); REPORT_DATE=15 April 2008; VALUE_TEXT=45; DOSE=SCCP/1126/07 Opinion on 2-amino-3-hydroxypyridine 21 In a 90-day study on rats, the NOAEL was set at 30 mg/kg bw/day, based on the histopathological changes in the liver.; EFFECT=SCCP/1126/07 Opinion on 2-amino-3-hydroxypyridine 21 In a 90-day study on rats, the NOAEL was set at 30 mg/kg bw/day, based on the histopathological changes in the liver. Because of the death of dams at the highest dose group the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, NOAEL for embryotoxicity is determined to be 45 mg/kg bw/day. Irritation / sensitisation Based on the criteria of the test system, 2-Amino-3-hydroxypyridine was not irritant to rabbit skin. Undiluted 2-Amino-3-hydroxypyridine was irritating to the rabbit eye. 2-Amino-3-hydroxypyridine was determined to be a non-sensitizer when tested up to the highe; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"16867-03-1","citation":"","dose":"SCCP/1126/07 Opinion on 2-amino-3-hydroxypyridine 21 In a 90-day study on rats, the NOAEL was set at 30 mg/kg bw/day, based on the histopathological changes in the liver.","duration":"90-day","effect":"SCCP/1126/07 Opinion on 2-amino-3-hydroxypyridine 21 In a 90-day study on rats, the NOAEL was set at 30 mg/kg bw/day, based on the histopathological changes in the liver. Because of the death of dams at the highest dose group the NOAEL of maternal toxicity is set to 45 mg/kg bw/day. Based on the increase in the incidence of rudimentary lumbar ribs and other variations in the highest exposure group, NOAEL for embryotoxicity is determined to be 45 mg/kg bw/day. Irritation / sensitisation Based on the criteria of the test system, 2-Amino-3-hydroxypyridine was not irritant to rabbit skin. Undiluted 2-Amino-3-hydroxypyridine was irritating to the rabbit eye. 2-Amino-3-hydroxypyridine was determined to be a non-sensitizer when tested up to the highe","endpoint":"irritation","ingredient":"in line","loael_value":"","noael_unit":"mg/kg bw/day","noael_value":"45","page":21,"route":"","species":"rat","study_id":"sccp_o_127_noael_008"}
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier P8740PEW4B UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H6N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P8740PEW4B"}
openFDA substances FDA UNII substance identifier P8740PEW4B UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H6N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P8740PEW4B"}
openFDA substances FDA UNII substance identifier P8740PEW4B UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H6N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P8740PEW4B"}
openFDA substances FDA UNII substance identifier P8740PEW4B UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H6N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P8740PEW4B"}