NOAEL Studies Cosmetic Ingredient

2-Amino-3-Hydroxypyridine NOAEL Studies

INCI: 2-AMINO-3-HYDROXYPYRIDINE

CAS: 16867-03-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 60 mg/kg bw/day rat oral 91 day Subchronic SCCP; Hruby, R. (2005) A 132: 90-day oral toxicity study with rats. ARC Seibersdorfresearch GmbH, Seibersdorf, Austria, internal study code: HE 92 Archive code atHenkel KGaA, Düsseldorf, Report No. R 0500256
COSMOS DB NOAEL 30 mg/kg bw/day rat oral 91 day Subchronic SCCP; Hruby, R. (2005) A 132: 90-day oral toxicity study with rats. ARC Seibersdorfresearch GmbH, Seibersdorf, Austria, internal study code: HE 92 Archive code atHenkel KGaA, Düsseldorf, Report No. R 0500256
SCCS Opinion 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.02 mg/kg bw rat oral 90-day dermal absorption p.20
SCCS Opinion NOAEL =30 mg/kg bw/day - - Chronic genotoxicity p.14
SCCS Opinion NOAEL =30 mg/kg bw rat oral 90-day dermal absorption p.20
SCCS Opinion NOAEL =45 mg/kg bw/day - - - NOAEL study p.19
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =30 mg/kg bw/day Rat oral chronic; 91 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c536a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20708/7/6/2?documentUUID=609ca98b-8aa6-46ba-af68-283e5f23fcbf; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=behaviour (functional findings)|urinalysis|water consumption and compound intake|body weight and weight gain|clinical biochemistry|food consumption and compound intake|gross pathology|haematology|histopathology: neoplastic|mortality|ophthalmological examination|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|food and/or water consumption|gross pathology|hematology|mortality/survival|neurobehavior|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15846346:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_716b947741141c1a81856c52d5a653f2
ECHA NOAEL =45 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabf4e4b0a7c65d1bca76; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20708/7/9/3?documentUUID=609ca98b-8aa6-46ba-af68-283e5f23fcbf; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: changes in postnatal survival|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821068:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e41dca4d15ed8329ec576759ccb9c1a
Regulatory source 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 45 mg/kg bw/day - - - - p.19
Regulatory source dermal absorption =0.02 mg/kg bw rat oral 90-day dermal absorption p.20
Regulatory source dermal absorption =30 mg/kg bw rat oral 90-day dermal absorption p.20
Regulatory source genotoxicity 30 mg/kg bw/day - - Chronic genotoxicity p.14
Regulatory source irritation 30 mg/kg bw/day rat - 90-day irritation p.21
Regulatory source irritation 45 mg/kg bw/day rat - 90-day irritation p.21
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier P8740PEW4B UNII - - - chemical -