NOAEL Studies Cosmetic Ingredient

2-Amino-4-Hydroxyethylaminoanisole Sulfate NOAEL Studies

INCI: 2-AMINO-4-HYDROXYETHYLAMINOANISOLE SULFATE

CAS: 83763-48-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB LOAEL 15 mg/kg bw/day rat oral 108 day Subchronic SCCS; Braun, W. H.; Repeated dose 90-day oral toxicity study with 2-Amino-4-hydroxyethylaminoanisole sulfate (A084, WR 23081) in Wistar Rats; RCC; 2005
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >150 mg/kg bw/day Rat oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac7be4b0a7c65d1bf4cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22865/7/9/3?documentUUID=b6d4ee79-3429-4688-9cf3-a0f398351b63; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=fetus: external malformations|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821801:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bdab62cc72454d6bb86c78b98cd78c6e
ToxValDB_ECHA_IUCLID NOAEL =30 mg/kg bw/day Rat oral - reproduction developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac7be4b0a7c65d1bf4cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22865/7/9/3?documentUUID=b6d4ee79-3429-4688-9cf3-a0f398351b63; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15823085:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6aa2ef7a5d3444f27d2b9cda680ee2e3
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Guinea Pig dermal short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d3ae4b096bca8774f85; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22865/7/6/4?documentUUID=b6d4ee79-3429-4688-9cf3-a0f398351b63; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15826093:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0185df93a9a314d93b2515c38c1a096d
ToxValDB_ECHA_IUCLID NOAEL =15 mg/kg bw/day Rat oral chronic; 108 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf22e4b0a7c65d1cc968; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22865/7/6/2?documentUUID=b6d4ee79-3429-4688-9cf3-a0f398351b63; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=clinical biochemistry|gross pathology|haematology|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|gross pathology|hematology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15833047:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_10b5b4e85312f30ec70e41606fd7324d
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier UM91A54Z8G UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H14N2O2.H2O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UM91A54Z8G"}
openFDA substances FDA UNII substance identifier UM91A54Z8G UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H14N2O2.H2O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UM91A54Z8G"}
openFDA substances FDA UNII substance identifier UM91A54Z8G UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H14N2O2.H2O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UM91A54Z8G"}
openFDA substances FDA UNII substance identifier UM91A54Z8G UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H14N2O2.H2O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UM91A54Z8G"}