Also known as: 2-[(3-amino-4-methoxyphenyl)amino]ethanol sulfate
INCI: 2-AMINO-4-HYDROXYETHYLAMINOANISOLE SULFATE
2-Amino-4-Hydroxyethylaminoanisole Sulfate (CAS 83763-48-8) is a cosmetic cosmetic ingredient functioning as Hair dyeing — oxidative coupling agent (sulfate salt). NOAEL 15 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited, max 1.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 83763-48-8 →
2-Amino-4-Hydroxyethylaminoanisole Sulfate is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H302, H315, H317, H319, H373, H400, H410, H411).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Amino-4-Hydroxyethylaminoanisole Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
3 study endpoints found for 2-Amino-4-Hydroxyethylaminoanisole Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =15 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =30 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | dermal | Guinea Pig | short-term | ToxValDB_ECHA_IUCLID |
Pre-calculated NOAEL → SED → MoS audit trail for 2-Amino-4-Hydroxyethylaminoanisole Sulfate across SCCS product categories, with measured dermal absorption where available.
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 1.5 | Oxidative hair dye products |
| KR | prohibited | - | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 1.54% | - | - | SCCP/0958/05 |
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Permanent Hair Color | 0.5–2 | 2 | CIR (IJT 32:2013) |
1 property record from structured ingredient metadata.
Expert safety assessment and concern-level summary for 2-Amino-4-Hydroxyethylaminoanisole Sulfate.
Public NOAEL study rows linked to 2-Amino-4-Hydroxyethylaminoanisole Sulfate by CAS number or substance name.
| Absorption % | Method | Vehicle |
|---|---|---|
| 1.54% | SCCS opinion extraction | - |
2-Amino-4-Hydroxyethylaminoanisole Sulfate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
2-Amino-4-Hydroxyethylaminoanisole Sulfate EU regulatory status: prohibited. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.
2-Amino-4-Hydroxyethylaminoanisole Sulfate functions as: Hair dyeing — oxidative coupling agent (sulfate salt). It is classified as a cosmetic ingredient in our database. CAS number: 83763-48-8.
The NOAEL (No Observed Adverse Effect Level) for 2-Amino-4-Hydroxyethylaminoanisole Sulfate is =15 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
2-Amino-4-Hydroxyethylaminoanisole Sulfate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
2-Amino-4-Hydroxyethylaminoanisole Sulfate is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H302, H315, H317, H319, H373, H400, H410, H411).
Check 2-Amino-4-Hydroxyethylaminoanisole Sulfate compliance across multiple jurisdictions:
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-Amino-4-Hydroxyethylaminoanisole Sulfate in your formulation.