Moderate Cosmetic Ingredient NOAEL Data

2-Amino-4-Hydroxyethylaminoanisole Sulfate

INCI: 2-AMINO-4-HYDROXYETHYLAMINOANISOLE SULFATE

CAS Number
83763-48-8
Function
Hair dyeing — oxidative coupling agent (sulfate salt)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
EU Max Conc. 1.5%
🇺🇸 US Status permitted
US Notes CIR concluded safe; used in 94 hair coloring formulations at 0.008–1.5%

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 2-Amino-4-Hydroxyethylaminoanisole Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 15 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Nitrosamine concern — must not be used with nitrosating agents; nitrosamine content <50 ppb required. Mandatory warning label per Annex III conditions.

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is 2-Amino-4-Hydroxyethylaminoanisole Sulfate safe in cosmetics?

Nitrosamine concern — must not be used with nitrosating agents; nitrosamine content <50 ppb required. Mandatory warning label per Annex III conditions. The EU classifies 2-Amino-4-Hydroxyethylaminoanisole Sulfate as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is 2-Amino-4-Hydroxyethylaminoanisole Sulfate allowed in the EU?

2-Amino-4-Hydroxyethylaminoanisole Sulfate EU regulatory status: prohibited. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Amino-4-Hydroxyethylaminoanisole Sulfate do in cosmetics?

2-Amino-4-Hydroxyethylaminoanisole Sulfate functions as: Hair dyeing — oxidative coupling agent (sulfate salt). It is classified as a cosmetic ingredient in our database. CAS number: 83763-48-8.

What is the Margin of Safety for 2-Amino-4-Hydroxyethylaminoanisole Sulfate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2-Amino-4-Hydroxyethylaminoanisole Sulfate?

The NOAEL (No Observed Adverse Effect Level) for 2-Amino-4-Hydroxyethylaminoanisole Sulfate is 15 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

📱

Is 2-Amino-4-Hydroxyethylaminoanisole Sulfate in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-Amino-4-Hydroxyethylaminoanisole Sulfate in your formulation.