NOAEL Studies Cosmetic Ingredient

2-Amino-4-Nitrophenol NOAEL Studies

INCI: 2-AMINO-4-NITROPHENOL

CAS: 119-34-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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California Proposition 65 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1999-01-29 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1999-01-29","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1999-01-29 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1999-01-29","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1999-01-29 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1999-01-29","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
IARC Monographs 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"16, Sup 7"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"16, Sup 7"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"16, Sup 7"}
NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =1470 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1575; row=9897; data_type=In Vivo; mixture=Chemical; chemical_name=4-Amino-2-nitrophenol; preferred_name=4-Amino-2-nitrophenol; dtxsid=DTXSID6020064; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020064; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020064; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =3300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1577; row=9896; data_type=In Vivo; mixture=Chemical; chemical_name=4-Amino-2-nitrophenol; preferred_name=4-Amino-2-nitrophenol; dtxsid=DTXSID6020064; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020064; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020064; source_file=acute_oral.xlsx
NTP ICE cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=6255; Record_ID=cancer_5965; Data_Type=WOE; Formulation_Name=4-Amino-2-nitrophenol; Mixture=Chemical; DTXSID=DTXSID6020064; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/34; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020064; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020064
NTP ICE cancer Top dose 2500 ppm Mouse - - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=6256; Record_ID=cancer_5963; Data_Type=In Vivo; Formulation_Name=4-Amino-2-nitrophenol; Mixture=Chemical; DTXSID=DTXSID6020064; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2500; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Reference=TR-094; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr094/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020064; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020064
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier N3499RCQ6B UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H6N2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N3499RCQ6B"}
openFDA substances FDA UNII substance identifier N3499RCQ6B UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H6N2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N3499RCQ6B"}
openFDA substances FDA UNII substance identifier N3499RCQ6B UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H6N2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N3499RCQ6B"}
openFDA substances FDA UNII substance identifier N3499RCQ6B UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H6N2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N3499RCQ6B"}