Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for 2-Amino-4-Nitrophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | 250 mg/kg bw/day | oral | mouse | oral | REACH |
Expert Verdict
Prohibited in EU and ASEAN markets despite CIR clearance; animal studies showed little evidence of systemic toxicity but regulatory restrictions remain in place.
Regulatory Flags
Frequently Asked Questions
Is 2-Amino-4-Nitrophenol safe in cosmetics?
Prohibited in EU and ASEAN markets despite CIR clearance; animal studies showed little evidence of systemic toxicity but regulatory restrictions remain in place. The EU classifies 2-Amino-4-Nitrophenol as "prohibited". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is 2-Amino-4-Nitrophenol allowed in the EU?
2-Amino-4-Nitrophenol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Amino-4-Nitrophenol do in cosmetics?
2-Amino-4-Nitrophenol functions as: Hair dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 119-34-6.
What is the Margin of Safety for 2-Amino-4-Nitrophenol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Amino-4-Nitrophenol?
The NOAEL (No Observed Adverse Effect Level) for 2-Amino-4-Nitrophenol is 250 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
Check 2-Amino-4-Nitrophenol compliance across multiple jurisdictions:
Related Ingredients
Is 2-Amino-4-Nitrophenol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-Amino-4-Nitrophenol in your formulation.