NOAEL Studies Cosmetic Ingredient

2-Amino-6-Chloro-4-Nitrophenol NOAEL Studies

INCI: 2-AMINO-6-CHLORO-4-NITROPHENOL

CAS: 6358-09-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =30 mg / kg / day rat oral subchronic repeated dose toxicity 2; 6; 4, p.1
COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 10 mg/kg bw/day rat oral 6-15 Gestation day Developmental SCCP; Korn W.D. Teratogenicity study with “Chlororange (Cos 198)” in Wistar rats;
NTP ICE skin sensitization 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization EC3 2.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13037; Record_ID=skin_sensitization_invivo_3007; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9043855; Assay=LLNA; Endpoint=EC3; Response=2.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9043855
NTP ICE skin sensitization EC3 6.85 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13059; Record_ID=skin_sensitization_invivo_3035; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9043855; Assay=LLNA; Endpoint=EC3; Response=6.85; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9043855
SCCS Opinion 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.065 mg/kg human dermal - dermal absorption p.25
SCCS Opinion NOAEL =30 mg/kg bw human - developmental developmental toxicity p.20
SCCS Opinion NOAEL =30 mg/kg human dermal - dermal absorption p.25
SCCS Opinion NOAEL =90 mg/kg bw human - developmental developmental toxicity p.20
SCCS Opinion NOAEL =2000 mg/kg bw rat oral subchronic repeated dose toxicity p.25
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL ~90 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae97e4b0a7c65d1c9ec0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22556/7/6/2?documentUUID=c3491fb5-58f5-4f28-8f0a-c136ac0622c4; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=kidney: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837562_15837563:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2ec83e5b774d3b21d2640d9d55fe27d8
ECHA NOAEL ~30 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae97e4b0a7c65d1c9ec0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22556/7/6/2?documentUUID=c3491fb5-58f5-4f28-8f0a-c136ac0622c4; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=kidney; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837562_15837563:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dacf51949b92f396fc1fced55e1799f9
ECHA NOAEL =90 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be54b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22556/7/9/3?documentUUID=c3491fb5-58f5-4f28-8f0a-c136ac0622c4; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID:15821786:F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_635c61606142e62a0451be8ad69a191d
Regulatory source 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source repeated dose toxicity 30 mg / kg / day rat oral subchronic repeated dose toxicity p.1
Regulatory source dermal absorption =0.065 mg/kg human dermal - dermal absorption p.25
Regulatory source dermal absorption =30 mg/kg human dermal - dermal absorption p.25
Regulatory source developmental toxicity 30 mg/kg bw human - developmental developmental toxicity p.20
Regulatory source developmental toxicity 90 mg/kg bw human - developmental developmental toxicity p.20
Regulatory source repeated dose toxicity 2000 mg/kg bw rat oral subchronic repeated dose toxicity p.25
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 0ZLP5I1TMC UNII - - - chemical -