NOAEL Studies Cosmetic Ingredient

2-Chloro-6-Ethylamino-4-Nitrophenol NOAEL Studies

INCI: 2-CHLORO-6-ETHYLAMINO-4-NITROPHENOL

CAS: 131657-78-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 10 mg/kg bw/day rat oral 90 day Subchronic SCCP; Korn, W.-D.; 3-month oral toxicity studywith "ROT CO" (Cos. 552) in rats (followedby a 4-week recovery period); IBR ;1989
SCCS Opinion 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =10 mg/kg bw rat - 90-day dermal absorption p.5
SCCS Opinion NOAEL =10 mg/kg rat oral 90-day dermal absorption p.28
SCCS Opinion NOAEL =90 mg/kg bw rat - 90-day dermal absorption p.5
Regulatory source 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 10 mg/kg bw rat - 4-week - p.16
Regulatory source dermal absorption 10 mg/kg bw rat - 90-day dermal absorption p.5
Regulatory source dermal absorption =10 mg/kg rat oral 90-day dermal absorption p.28
Regulatory source dermal absorption 90 mg/kg bw rat - 90-day dermal absorption p.5
Regulatory source developmental toxicity 10 mg/kg bw rat oral 90 days developmental toxicity p.28
Regulatory source developmental toxicity 90 mg/kg bw rat - developmental developmental toxicity p.25
Regulatory source developmental toxicity 90 mg/kg bw rat dermal 90 days developmental toxicity p.28
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5LIV96LADQ UNII - - - chemical -