NOAEL Studies Cosmetic Ingredient

2-Chloro-P-Phenylenediamine NOAEL Studies

INCI: 2-CHLORO-P-PHENYLENEDIAMINE

CAS: 615-66-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =100 mg/kg bw/d rat - developmental developmental toxicity p.18
SCCS Opinion NOAEL =200 mg/kg bw/d rat - developmental developmental toxicity p.18
ToxValDB ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX NOEL =63 mg/kg bw/day Rat oral acute; 0.875 days acute LONG_REF=Teratog. Carcinog. Mutagen.13(4): 167-184 Kitchin,K.T., J.L. Brown, and A.P. Kulkarni Predicting Rodent Carcinogenicity of Halogenated Hydrocarbons by In Vivo Biochemical Parameters 1993; TITLE=Predicting Rodent Carcinogenicity of Halogenated Hydrocarbons by In Vivo Biochemical Parameters; AUTHOR=Kitchin,K.T., J.L. Brown, and A.P. Kulkarni; DOI=10.1002/tcm.1770130403; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=70486; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Enzyme(s): Cytochrome P-450; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606088_15606089_15606090:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e0d735311f725a174cae8757eca8d4dc
ToxValDB ECOTOX NOEL =189 mg/kg bw/day Rat oral acute; 0.875 days acute LONG_REF=Teratog. Carcinog. Mutagen.13(4): 167-184 Kitchin,K.T., J.L. Brown, and A.P. Kulkarni Predicting Rodent Carcinogenicity of Halogenated Hydrocarbons by In Vivo Biochemical Parameters 1993; TITLE=Predicting Rodent Carcinogenicity of Halogenated Hydrocarbons by In Vivo Biochemical Parameters; AUTHOR=Kitchin,K.T., J.L. Brown, and A.P. Kulkarni; DOI=10.1002/tcm.1770130403; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=70486; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606088_15606089_15606090:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5ac4d8901ccc2602f06a8f0e09798b32
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =3.29 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f129c9b7f8468ca89c88d188e3cb1527
Regulatory source 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 100 mg/kg bw/d rat - developmental developmental toxicity p.18
Regulatory source developmental toxicity 200 mg/kg bw/d rat - developmental developmental toxicity p.18
Regulatory source repeated dose toxicity 100 mg/kg bw/d rat - subchronic repeated dose toxicity p.19
Regulatory source repeated dose toxicity 200 mg/kg bw/d rat - subchronic repeated dose toxicity p.19
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier W949BCC82R UNII - - - chemical -