NOAEL Studies Cosmetic Ingredient

2-Chloro-P-Phenylenediamine NOAEL Studies

INCI: 2-CHLORO-P-PHENYLENEDIAMINE

CAS: 615-66-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS_vision_codex 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS_vision_codex NOAEL =100 mg/kg bw/d rat - developmental developmental toxicity {"citation":"Ref.: 11 SCCS comment The evaluation was a published study","dose":"__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d.","effect":"__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old","page":18,"pdf":"sccs_o_139.pdf","row_type":"noael_study","study_id":"sccs_o_139_noael_001"}
SCCS_vision_codex NOAEL =200 mg/kg bw/d rat - developmental developmental toxicity {"citation":"Ref.: 11 SCCS comment The evaluation was a published study","dose":"Rats given the high dose revealed a significant reduction in male and female foetal body weights.","effect":"d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old woman developed an eczematous reaction after use of a cream dye on her lashes and brows. She had used the","page":18,"pdf":"sccs_o_139.pdf","row_type":"noael_study","study_id":"sccs_o_139_noael_002"}
SCCS_vision_codex NOAEL =100 mg/kg bw/d rat - developmental developmental toxicity {"citation":"Ref.: 11 SCCS comment The evaluation was a published study","dose":"__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d.","effect":"__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old","page":18,"pdf":"sccs_o_139.pdf","row_type":"noael_study","study_id":"sccs_o_139_noael_001"}
SCCS_vision_codex NOAEL =200 mg/kg bw/d rat - developmental developmental toxicity {"citation":"Ref.: 11 SCCS comment The evaluation was a published study","dose":"Rats given the high dose revealed a significant reduction in male and female foetal body weights.","effect":"d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old woman developed an eczematous reaction after use of a cream dye on her lashes and brows. She had used the","page":18,"pdf":"sccs_o_139.pdf","row_type":"noael_study","study_id":"sccs_o_139_noael_002"}
SCCS_vision_codex NOAEL =100 mg/kg bw/d rat - developmental developmental toxicity {"citation":"Ref.: 11 SCCS comment The evaluation was a published study","dose":"__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d.","effect":"__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old","page":18,"pdf":"sccs_o_139.pdf","row_type":"noael_study","study_id":"sccs_o_139_noael_001"}
SCCS_vision_codex NOAEL =200 mg/kg bw/d rat - developmental developmental toxicity {"citation":"Ref.: 11 SCCS comment The evaluation was a published study","dose":"Rats given the high dose revealed a significant reduction in male and female foetal body weights.","effect":"d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old woman developed an eczematous reaction after use of a cream dye on her lashes and brows. She had used the","page":18,"pdf":"sccs_o_139.pdf","row_type":"noael_study","study_id":"sccs_o_139_noael_002"}
SCCS_vision_codex NOAEL =100 mg/kg bw/d rat - developmental developmental toxicity {"citation":"Ref.: 11 SCCS comment The evaluation was a published study","dose":"__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d.","effect":"__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old","page":18,"pdf":"sccs_o_139.pdf","row_type":"noael_study","study_id":"sccs_o_139_noael_001"}
SCCS_vision_codex NOAEL =200 mg/kg bw/d rat - developmental developmental toxicity {"citation":"Ref.: 11 SCCS comment The evaluation was a published study","dose":"Rats given the high dose revealed a significant reduction in male and female foetal body weights.","effect":"d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old woman developed an eczematous reaction after use of a cream dye on her lashes and brows. She had used the","page":18,"pdf":"sccs_o_139.pdf","row_type":"noael_study","study_id":"sccs_o_139_noael_002"}
ToxValDB_ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX NOEL =63 mg/kg bw/day Rat oral acute; 0.875 days acute LONG_REF=Teratog. Carcinog. Mutagen.13(4): 167-184 Kitchin,K.T., J.L. Brown, and A.P. Kulkarni Predicting Rodent Carcinogenicity of Halogenated Hydrocarbons by In Vivo Biochemical Parameters 1993; TITLE=Predicting Rodent Carcinogenicity of Halogenated Hydrocarbons by In Vivo Biochemical Parameters; AUTHOR=Kitchin,K.T., J.L. Brown, and A.P. Kulkarni; DOI=10.1002/tcm.1770130403; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=70486; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Enzyme(s): Cytochrome P-450; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606088_15606089_15606090:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e0d735311f725a174cae8757eca8d4dc
ToxValDB_ECOTOX NOEL =189 mg/kg bw/day Rat oral acute; 0.875 days acute LONG_REF=Teratog. Carcinog. Mutagen.13(4): 167-184 Kitchin,K.T., J.L. Brown, and A.P. Kulkarni Predicting Rodent Carcinogenicity of Halogenated Hydrocarbons by In Vivo Biochemical Parameters 1993; TITLE=Predicting Rodent Carcinogenicity of Halogenated Hydrocarbons by In Vivo Biochemical Parameters; AUTHOR=Kitchin,K.T., J.L. Brown, and A.P. Kulkarni; DOI=10.1002/tcm.1770130403; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=70486; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606088_15606089_15606090:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5ac4d8901ccc2602f06a8f0e09798b32
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =3.29 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f129c9b7f8468ca89c88d188e3cb1527
UnifiedCodex:SCCS_SHADOW:beta.noael_studies 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
UnifiedCodex:SCCS_SHADOW:beta.noael_studies developmental toxicity 100 mg/kg bw/d rat - developmental developmental toxicity SOURCE_SUBDIR=sccs_o_139; REPORT_TITLE=OPINION ON 2-Chloro-p-phenylenediamine COLIPA n° A8; OPINION_NUMBER=SCCS/1510/13; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=19 September 2013; VALUE_TEXT=100; DOSE=__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d.; EFFECT=__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old; CITATION=Ref.: 11 SCCS comment The evaluation was a published study; CITATION_NUMBERS=[11]; REFERENCE=Ref.: 11 SCCS comment The evaluation was a published study; DETAILS_JSON={"cas_number":"615-66-7","citation":"Ref.: 11 SCCS comment The evaluation was a published study","dose":"__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d.","duration":"developmental","effect":"__________ 18 Maternal body weight gain was significantly reduced at the dose levels 200 and 400 mg/kg bw/d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old","endpoint":"developmental toxicity","ingredient":"at its 48th","loael_value":"","noael_unit":"mg/kg bw/d","noael_value":"100","page":18,"route":"","species":"rat","study_id":"sccs_o_139_noael_001"}
UnifiedCodex:SCCS_SHADOW:beta.noael_studies developmental toxicity 200 mg/kg bw/d rat - developmental developmental toxicity SOURCE_SUBDIR=sccs_o_139; REPORT_TITLE=OPINION ON 2-Chloro-p-phenylenediamine COLIPA n° A8; OPINION_NUMBER=SCCS/1510/13; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=19 September 2013; VALUE_TEXT=200; DOSE=Rats given the high dose revealed a significant reduction in male and female foetal body weights.; EFFECT=d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old woman developed an eczematous reaction after use of a cream dye on her lashes and brows. She had used the; CITATION=Ref.: 11 SCCS comment The evaluation was a published study; CITATION_NUMBERS=[11]; REFERENCE=Ref.: 11 SCCS comment The evaluation was a published study; DETAILS_JSON={"cas_number":"615-66-7","citation":"Ref.: 11 SCCS comment The evaluation was a published study","dose":"Rats given the high dose revealed a significant reduction in male and female foetal body weights.","duration":"developmental","effect":"d. Rats given the high dose revealed a significant reduction in male and female foetal body weights. Evaluation of foetuses for gross, visceral and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups, but showed a significant increase (up to 25-91%) in the incidence of abnormal foetuses in the group exposed to Vitamin A; the positive control. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. Ref.: 11 SCCS comment The evaluation was a published study. The study did not follow a guideline. 3.3.9. Toxicokinetics 3.3.10. Photo-induced toxicity 3.3.10.1. Phototoxicity / photoirritation and photosensitisation No data available 3.3.10.2. Phototoxicity / photomutagenicity / photoclastogenicity 3.3.11. Human data A 29 year old woman developed an eczematous reaction after use of a cream dye on her lashes and brows. She had used the","endpoint":"developmental toxicity","ingredient":"at its 48th","loael_value":"","noael_unit":"mg/kg bw/d","noael_value":"200","page":18,"route":"","species":"rat","study_id":"sccs_o_139_noael_002"}
UnifiedCodex:SCCS_SHADOW:beta.noael_studies repeated dose toxicity 100 mg/kg bw/d rat - subchronic repeated dose toxicity SOURCE_SUBDIR=sccs_o_139; REPORT_TITLE=OPINION ON 2-Chloro-p-phenylenediamine COLIPA n° A8; OPINION_NUMBER=SCCS/1510/13; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=19 September 2013; VALUE_TEXT=100; DOSE=Stability of 2-chloro-p-phenylenediamine in typical hair dye formulation was not provided General toxicity The LD50 in rats was reported to be 1190 mg/kg bw and 729 mg/kg bw in different studies No study details are available.; EFFECT=not provided. Stability of 2-chloro-p-phenylenediamine in typical hair dye formulation was not provided General toxicity The LD50 in rats was reported to be 1190 mg/kg bw and 729 mg/kg bw in different studies No study details are available. A subchronic toxicity study with 2-chloro-p-phenylenediamine sulfate was mentioned in a review paper. The study is not available. No conclusion can be derived with regard to subchronic toxicity. The results of teratogenicity study in rats were reported in a publication. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. However, the study did not follow a guideline. Irritation / sensitisation; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"615-66-7","citation":"","dose":"Stability of 2-chloro-p-phenylenediamine in typical hair dye formulation was not provided General toxicity The LD50 in rats was reported to be 1190 mg/kg bw and 729 mg/kg bw in different studies No study details are available.","duration":"subchronic","effect":"not provided. Stability of 2-chloro-p-phenylenediamine in typical hair dye formulation was not provided General toxicity The LD50 in rats was reported to be 1190 mg/kg bw and 729 mg/kg bw in different studies No study details are available. A subchronic toxicity study with 2-chloro-p-phenylenediamine sulfate was mentioned in a review paper. The study is not available. No conclusion can be derived with regard to subchronic toxicity. The results of teratogenicity study in rats were reported in a publication. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. However, the study did not follow a guideline. Irritation / sensitisation","endpoint":"repeated dose toxicity","ingredient":"at its 48th","loael_value":"","noael_unit":"mg/kg bw/d","noael_value":"100","page":19,"route":"","species":"rat","study_id":"sccs_o_139_noael_003"}
UnifiedCodex:SCCS_SHADOW:beta.noael_studies repeated dose toxicity 200 mg/kg bw/d rat - subchronic repeated dose toxicity SOURCE_SUBDIR=sccs_o_139; REPORT_TITLE=OPINION ON 2-Chloro-p-phenylenediamine COLIPA n° A8; OPINION_NUMBER=SCCS/1510/13; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=19 September 2013; VALUE_TEXT=200; DOSE=eneral toxicity The LD50 in rats was reported to be 1190 mg/kg bw and 729 mg/kg bw in different studies No study details are available.; EFFECT=eneral toxicity The LD50 in rats was reported to be 1190 mg/kg bw and 729 mg/kg bw in different studies No study details are available. A subchronic toxicity study with 2-chloro-p-phenylenediamine sulfate was mentioned in a review paper. The study is not available. No conclusion can be derived with regard to subchronic toxicity. The results of teratogenicity study in rats were reported in a publication. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. However, the study did not follow a guideline. Irritation / sensitisation; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"615-66-7","citation":"","dose":"eneral toxicity The LD50 in rats was reported to be 1190 mg/kg bw and 729 mg/kg bw in different studies No study details are available.","duration":"subchronic","effect":"eneral toxicity The LD50 in rats was reported to be 1190 mg/kg bw and 729 mg/kg bw in different studies No study details are available. A subchronic toxicity study with 2-chloro-p-phenylenediamine sulfate was mentioned in a review paper. The study is not available. No conclusion can be derived with regard to subchronic toxicity. The results of teratogenicity study in rats were reported in a publication. The NOAEL of maternal toxicity is 100 mg/kg bw/d, that of developmental toxicity is 200 mg/kg bw/d whereas the NOAEL teratogenicity from this study can be estimated to be 400 mg/kg bw/d. However, the study did not follow a guideline. Irritation / sensitisation","endpoint":"repeated dose toxicity","ingredient":"at its 48th","loael_value":"","noael_unit":"mg/kg bw/d","noael_value":"200","page":19,"route":"","species":"rat","study_id":"sccs_o_139_noael_004"}
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier W949BCC82R UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7ClN2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W949BCC82R"}
openFDA substances FDA UNII substance identifier W949BCC82R UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7ClN2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W949BCC82R"}
openFDA substances FDA UNII substance identifier W949BCC82R UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7ClN2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W949BCC82R"}
openFDA substances FDA UNII substance identifier W949BCC82R UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7ClN2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W949BCC82R"}