NOAEL Studies Cosmetic Ingredient

2-Hydroxyethyl Picramic Acid NOAEL Studies

INCI: 2-HYDROXYETHYL PICRAMIC ACID

CAS: 99610-72-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 20 mg/kg bw/day rat oral 91 day Subchronic SCCP; Weide, J.; 3-monatige Toxizitätsprüfung an Ratten mit der Testsubstanz Pikraminrot;WELLA AG; 1985
SCCS Opinion 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.13 mg/kg bw rat oral 90-day dermal absorption p.27
SCCS Opinion NOAEL =0.16 mg/kg bw rat oral 90-day dermal absorption p.26
SCCS Opinion NOAEL =15 mg/kg bw rat - Chronic genotoxicity p.18
SCCS Opinion NOAEL =20 mg/kg bw rat - - NOAEL study p.17
SCCS Opinion NOAEL =20 mg/kg bw/day rat - 90 days reproductive toxicity p.27
SCCS Opinion NOAEL =50 mg/kg bw - oral Sub-chronic repeated dose toxicity Ref.: 13 (submission I) 3, p.17
SCCS Opinion NOAEL =50 mg/kg bw/day human - 12 to day NOAEL study p.25
SCCS Opinion NOAEL =60 mg/kg bw rat - 90 days reproductive toxicity p.27
SCCS Opinion NOAEL =120 mg/kg bw/day rat oral 28-day reproductive toxicity p.25
SCCS Opinion NOAEL =120 mg/kg bw rabbit dermal 28-day reproductive toxicity p.27
Regulatory source 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 20 mg/kg bw rat - - - p.17
Regulatory source - 50 mg/kg bw/day human - 12 to day - p.25
Regulatory source dermal absorption =0.13 mg/kg bw rat oral 90-day dermal absorption p.27
Regulatory source dermal absorption =0.16 mg/kg bw rat oral 90-day dermal absorption p.26
Regulatory source dermal absorption =20 mg/kg bw rat oral 90-day dermal absorption p.26
Regulatory source genotoxicity 15 mg/kg bw rat - Chronic genotoxicity p.18
Regulatory source repeated dose toxicity 50 mg/kg bw - oral Sub-chronic repeated dose toxicity p.17
Regulatory source reproductive toxicity 20 mg/kg bw/day rat - 90 days reproductive toxicity p.27
Regulatory source reproductive toxicity 50 mg/kg bw/day rat - 90 days reproductive toxicity p.27
Regulatory source reproductive toxicity 60 mg/kg bw rat - 90 days reproductive toxicity p.27
Regulatory source reproductive toxicity 120 mg/kg bw/day rat oral 28-day reproductive toxicity p.25
Regulatory source reproductive toxicity 120 mg/kg bw rabbit dermal 28-day reproductive toxicity p.27
Regulatory source reproductive toxicity 120 mg/kg bw rabbit - 28-day reproductive toxicity p.27
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier KZ27KOJ0GZ UNII - - - chemical -