NOAEL Studies Cosmetic Ingredient

2-Hydroxyethylamino-5-Nitroanisole NOAEL Studies

INCI: 2-HYDROXYETHYLAMINO-5-NITROANISOLE

CAS: 66095-81-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 25 mg/kg bw/day rat oral 90 day Subchronic SCCS; S-A. Brownlie. Imexine FM: 13 Week Oral (Gavage) Toxicity Study in the Rat. Quintiles Study No. LRL/81/95, 1997
SCCS Opinion 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =100 mg/kg/day rat oral 28 day dermal absorption p.5
SCCS Opinion NOAEL =100 mg/kg bw/day - oral 13 weeks NOAEL study p.13
SCCS Opinion NOAEL =250 mg/kg bw/day human oral - NOAEL study p.18
Regulatory source 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg bw/day - oral 13 weeks - p.13
Regulatory source - 250 mg/kg bw/day human oral - - p.18
Regulatory source dermal absorption 100 mg/kg/day rat oral 28 day dermal absorption p.5
Regulatory source dermal absorption 100 mg/kg bw/day rat oral 90-day dermal absorption p.19
Regulatory source irritation 100 mg/kg bw/day rat oral 90-day irritation p.19
Regulatory source repeated dose toxicity 100 mg/kg bw/day rat oral subchronic repeated dose toxicity p.13
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 249S4E2270 UNII - - - chemical -