2-Hydroxyethylamino-5-Nitroanisole
INCI: 2-HYDROXYETHYLAMINO-5-NITROANISOLE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 2-Hydroxyethylamino-5-Nitroanisole. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 25 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Acute oral toxicity: non-lethal dose 500 mg/kg bw, lethal dose 1000 mg/kg bw in rats; no teratogenic effects up to 250 mg/kg bw/day
Regulatory Flags
Frequently Asked Questions
Is 2-Hydroxyethylamino-5-Nitroanisole safe in cosmetics?
Acute oral toxicity: non-lethal dose 500 mg/kg bw, lethal dose 1000 mg/kg bw in rats; no teratogenic effects up to 250 mg/kg bw/day The EU classifies 2-Hydroxyethylamino-5-Nitroanisole as "prohibited". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is 2-Hydroxyethylamino-5-Nitroanisole allowed in the EU?
2-Hydroxyethylamino-5-Nitroanisole EU regulatory status: prohibited. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Hydroxyethylamino-5-Nitroanisole do in cosmetics?
2-Hydroxyethylamino-5-Nitroanisole functions as: Hair dyeing — semi-permanent (non-oxidative) direct dye. It is classified as a cosmetic ingredient in our database. CAS number: 66095-81-6.
What is the Margin of Safety for 2-Hydroxyethylamino-5-Nitroanisole?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Hydroxyethylamino-5-Nitroanisole?
The NOAEL (No Observed Adverse Effect Level) for 2-Hydroxyethylamino-5-Nitroanisole is 25 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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