NOAEL Studies Cosmetic Ingredient

2-Methyl-1-Naphthol NOAEL Studies

CAS: 7469-77-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 225 mg/kg bw/day rat oral 6-20 Gestation day Developmental SCCP; Oral (Gavage) Developmental Toxicity Study Of GTS03958 In Rats, P&G Study # 2718-53858, October 2005
COSMOS DB NOAEL 75 mg/kg bw/day rat oral 6-20 Gestation day Developmental SCCP; Oral (Gavage) Developmental Toxicity Study Of GTS03958 In Rats, P&G Study # 2718-53858, October 2005
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.07 mg/kg bw rat oral - dermal absorption p.26
SCCS Opinion NOAEL =75 mg/kg bw/day - oral developmental developmental toxicity p.25
SCCS Opinion NOAEL =75 mg/kg bw rat oral - dermal absorption p.26
SCCS Opinion NOAEL =100 mg/kg bw/day - oral Chronic genotoxicity p.17
SCCS Opinion NOAEL =225 mg/kg bw/day - - developmental developmental toxicity p.25
SCCS Opinion NOAEL =500 mg/kg bw/day rat oral 14-days repeated dose toxicity p.15
Regulatory source 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source dermal absorption =0.07 mg/kg bw rat oral - dermal absorption p.26
Regulatory source dermal absorption =75 mg/kg bw rat oral - dermal absorption p.26
Regulatory source developmental toxicity 75 mg/kg bw/day - oral developmental developmental toxicity p.25
Regulatory source developmental toxicity 75 mg/kg bw/day rat oral 14-day developmental toxicity p.26
Regulatory source developmental toxicity 100 mg/kg bw/day rat oral 14-day developmental toxicity p.26
Regulatory source developmental toxicity 225 mg/kg bw/day - - developmental developmental toxicity p.25
Regulatory source developmental toxicity 225 mg/kg bw/day rat oral 14-day developmental toxicity p.26
Regulatory source developmental toxicity 500 mg/kg bw/day rat oral 14-day developmental toxicity p.26
Regulatory source genotoxicity 100 mg/kg bw/day - oral Chronic genotoxicity p.17
Regulatory source repeated dose toxicity 500 mg/kg bw/day rat oral 14-days repeated dose toxicity p.15
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier COU5JQ433I UNII - - - chemical -