Moderate Cosmetic Ingredient NOAEL Data

2-Methyl-1-Naphthol

CAS Number
7469-77-4
Function
Dye
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 2.0%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FD&C Act ยง601 hair dye exemption applies; requires patch-test warning

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for 2-Methyl-1-Naphthol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 75 mg/kg bw/day oral rat Developmental COSMOS_DB
LOAEL 225 mg/kg bw/day oral rat Developmental COSMOS_DB

Expert Verdict

Restricted oxidative hair dye coupler with concentration limits; not permitted for fragrance use; requires patch-test warning and full hair dye labeling compliance.

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Concern Level: Moderate

Regulatory Flags

eu_cosing_listed

Frequently Asked Questions

Is 2-Methyl-1-Naphthol safe in cosmetics?

Restricted oxidative hair dye coupler with concentration limits; not permitted for fragrance use; requires patch-test warning and full hair dye labeling compliance. The EU classifies 2-Methyl-1-Naphthol as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is 2-Methyl-1-Naphthol allowed in the EU?

2-Methyl-1-Naphthol EU regulatory status: restricted. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Methyl-1-Naphthol do in cosmetics?

2-Methyl-1-Naphthol functions as: Dye. It is classified as a cosmetic ingredient in our database. CAS number: 7469-77-4.

What is the Margin of Safety for 2-Methyl-1-Naphthol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2-Methyl-1-Naphthol?

The NOAEL (No Observed Adverse Effect Level) for 2-Methyl-1-Naphthol is 75 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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