NOAEL Studies Cosmetic Ingredient

2-Methyl-3-Buten-2-Ol NOAEL Studies

CAS: 115-18-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 1250 mg/kg bw/day mouse oral 3 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >21.2 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2172; Record_ID=acute_inhalation_2942; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3047471; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=21.2; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11701/7/3/3/?documentUUID=77172c20-72a4-4e0c-bdc0-8ad131198670; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3047471
ECHA 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL =85220 mg/m3 Rat inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29841/7/3/3?documentUUID=04064e0f-1960-4465-b90a-db73ca62bae2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15798185_15798186:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fb10f9851755cb1af5ef34ccdfd07393
ECHA LEL =112250 mg/m3 Rat inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29841/7/3/3?documentUUID=04064e0f-1960-4465-b90a-db73ca62bae2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15798185_15798186:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_24c627e69f8224e9645351e81548e941
ECHA LOAEL =200 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaceee4b0a7c65d1c1909; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29841/7/6/2?documentUUID=04064e0f-1960-4465-b90a-db73ca62bae2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836310_15850449:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_08deb4c2aaaea089308aeffb50ead7df
ECHA NOAEL =50 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaceee4b0a7c65d1c1909; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29841/7/6/2?documentUUID=04064e0f-1960-4465-b90a-db73ca62bae2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836310_15850449:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_08d9df17fdc37675aba5161a30c48918
ECHA NOAEL =150 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaceee4b0a7c65d1c190b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29841/7/6/2?documentUUID=04064e0f-1960-4465-b90a-db73ca62bae2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15850450:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_979631dfdcc27865ba7ef84e34a34d8a
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier SH64HE46L9 UNII - - - chemical -