NOAEL Studies Cosmetic Ingredient

2-Methyl-5-Hydroxyethylaminophenol NOAEL Studies

INCI: 2-METHYL-5-HYDROXYETHYLAMINOPHENOL

CAS: 55302-96-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 50 mg/kg bw/day rat oral 90 day Subchronic SCCP; J. Richard. Imexine OAG: 13-Week Toxicity Study by Oral Route in Rats. CIT Study No.9438 TCR (CIES1 92095), 1993
NTP ICE skin sensitization 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization EC3 0.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13434; Record_ID=skin_sensitization_invivo_3583; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID70203849; Assay=LLNA; Endpoint=EC3; Response=0.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID70203849
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.053 mg/kg rat oral 90 day dermal absorption p.19
SCCS Opinion NOAEL =220 mg/kg bw - oral subchronic repeated dose toxicity p.12
SCCS Opinion NOAEL =220 mg/kg rat oral 90 day dermal absorption p.19
SCCS Opinion NOAEL =1000 mg/kg bw/d human oral - NOAEL study p.18
SCCS Opinion NOAEL =1800 mg/kg bw/d rat oral developmental developmental toxicity p.17
SCCS Opinion NOAEL >2000 mg/kg bw rat - subchronic repeated dose toxicity p.19
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =220 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae66e4b0a7c65d1c917c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21638/7/6/2?documentUUID=5215fe22-0bef-47d2-bd2f-e948bab4c937; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|urinalysis; STUDY_GROUP=ECHA IUCLID:15836564:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_95624a89c3cf6e243fecbd818190d9d1
ECHA NOAEL =1000 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be111; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21638/7/9/3?documentUUID=5215fe22-0bef-47d2-bd2f-e948bab4c937; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15821641:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_43a6c72938deac0b41a6cd64062c569c
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =7.8 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632684:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cbea58cead046ae979b968bf051c72c5
Regulatory source 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 1000 mg/kg bw/d human oral - - p.18
Regulatory source dermal absorption =0.053 mg/kg rat oral 90 day dermal absorption p.19
Regulatory source dermal absorption =220 mg/kg rat oral 90 day dermal absorption p.19
Regulatory source developmental toxicity 1800 mg/kg bw/d rat oral developmental developmental toxicity p.17
Regulatory source repeated dose toxicity 220 mg/kg bw - oral subchronic repeated dose toxicity p.12
Regulatory source repeated dose toxicity 220 mg/kg bw rat - subchronic repeated dose toxicity p.19
Regulatory source repeated dose toxicity >2000 mg/kg bw rat - subchronic repeated dose toxicity p.19
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier T872B9E83J UNII - - - chemical -